美多巴及溴隐亭配合高压氧治疗对脑损伤昏迷患者的临床疗效分析

Clinical efficacy analysis of Madopar and Bromocriptine combined with hyperbaric oxygen in patients with coma after brain damage

目的观察美多巴及溴隐亭配合高压氧治疗对脑损伤昏迷患者的临床疗效。方法回顾性分析2017年1月至2018年1月中南大学湘雅二医院收治的脑损伤昏迷患者62例,均接受高压氧治疗。按治疗方法不同分为对照组和治疗组各31例,对照组采用常规治疗联合高压氧治疗,治疗组在对照组基础上加用美多巴及溴隐亭治疗,分析2组患者治疗前后的格拉斯哥昏迷评分(GCS)及临床疗效。结果(1)对照组患者治愈率及总有效率明显高于治疗组(P<0.05);(2)对照组治疗后第3、7、14、28、60天GCS较治疗前及治疗组明显提高(P<0.05),治疗组治疗后第14、28、60天GCS较治疗前明显提高(P<0.05)。结论美多巴及溴隐亭可降低高压氧对脑损伤昏迷患者的临床疗效并延迟促醒时间。

Objective To study the clinical efficacy of Madopar and Bromocriptine in combination with hyperbaric oxygen(HBO)in patients with coma after brain damage.Methods A retrospective analysis of 62 cases of patients with coma after brain damage treated with HBO therapy in the Second Xiangya Hospital of Central South University from January 2017 to January 2018 was conducted.According to the treatment,the patients were divided into control group and treatment group,with 31 cases in each group.The control group received conventional treatment and HBO,while the treatment group received Madopar and Bromocriptine on the basis of the treatment of the control group.The scores of Glasgow coma scale(GCS)and the clinical efficacy were evaluated before and after treatment.Results①The cure rate and the total effective rate in the control group were significantly higher than those in the treatment group(P<0.05);②The GCS scores in the control group on day 3,7,14,28,and 60 after treatment were significantly higher than those before treatment and those in the treatment group(P<0.05).Within the treatment group,the GCS scores on day 14,28,and 60 companed with those before treatment were also significantly improved after treatment(P<0.05).Conclusion Madopar and Bromocriptine have an adverse impact on the clinical efficacy of HBO in patients with coma after brain damage and delay their wake-up.