新疆地区LIPG和GUCY1A3基因多态性与冠心病的相关性研究

Relationship between LIPG and GUCY1A3 gene polymorphisms and coronary heart disease in Xinjiang

目的:探讨新疆地区人群中GUCY1A3的rs7692307及LIPG的rs2000813、rs3813082基因的单核苷酸多态性(SNPs)与冠心病的相关性。方法:纳入研究对象共1883例,其中冠心病组959例,对照组924例,检测GUCY1A3、LIPG基因的SNPs位点多态性。结果:GUCY1A3 rs7692307均为GG基因型,无研究意义。两组间比较后,LIPG rs3813082、rs2000813基因型频率和等位基因频率均无明显差异。根据性别分层后,女性人群中LIPG rs2000813基因型分布频率在两组中有显著差异(P<0.05),且LIPG rs2000813位点上的C等位基因是女性冠心病的独立危险因素之一。结论:LIPG rs2000813位点上的C等位基因对于冠心病的发生具有性别特异性,是女性冠心病的独立危险因素之一,而未见其对男性冠心病的发生有影响。

Objective:To investigate the correlation between GUCY1 A3 rs7692307 and LIPG single nucleotide polymorphisms(SNPs)of rs2000813,rs3813082 genes and coronary heart disease in Xinjiang population.Methods:A total of 1883 cases were included in the study,including 959 cases in the coronary heart disease group and 924 cases in the control group.The SNPs of GUCY1 A31 A3 and LIPG genes were detected.Results:GUCY1 A3 rs 7692307 were GG genotypes and had no significance.There was no significant difference in LIPG rs3813082,rs2000813 genotype frequency and allele frequency between the two groups.The distribution frequency of LIPG rs2000813 genotypes in female population was significantly different(P<0.05),and the C allele at the LIPG rs2000813 locus was one of the independent risk factors for coronary heart disease in female.Conclusion:C alleles at the LIPG rs2000813 locus are gender specific to the occurrence of coronary heart disease,which is one of the independent risk factors for coronary heart disease in female,but there is no effect on the occurrence risk of coronary heart disease in male.