血清骨钙素水平与老年2型糖尿病病人慢性炎症指标的相关性

Correlation between serum osteocalcin level and chronic inflammation in elderly patients with type 2 diabetes mellitus

目的探讨在老年2型糖尿病(T2DM)病人中,血清骨钙素(OC)水平与慢性炎症指标的相关性。方法选取2018年6月至2020年3月在华东师范大学附属芜湖医院老年医学科住院的192例病人作为研究对象,分为T2DM组92例,非T2DM组100例,比较两组受试者血清OC水平、一般生化指标以及慢性炎症指标的关系,并分析在T2DM组中,血清OC水平与慢性炎症指标的关系。结果老年T2DM病人的血清OC水平较非T2DM组显著下降[(10.46±4.02)ng/mL比(15.76±5.81)ng/mL,P<0.01],而空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2hPG)、血清铁蛋白(SF)、超敏C反应蛋白(Hs-CRP)、单核细胞计数(MONO)较非T2DM组显著升高[(10.05±3.48)mmol/L比(5.18±0.70)mmol/L、(8.18±1.47)%比(5.51±0.31)%、(7.24±0.57)mmol/L比(5.46±0.29)mmol/L、(224.09±190.01)ng/mL比(146.06±133.01)ng/mL、(2.71±0.97)mmol/L比(2.10±0.76)mmol/L、(0.42±0.16)×10^(9)/L比(0.37±0.12)×10^(9)/L,P<0.01]。在老年T2DM病人中,相关性分析提示血清OC水平与SF、Hs-CRP、嗜酸性粒细胞计数(EO)呈负相关;校正血糖、BMI后进行多元回归分析发现,SF、Hs-CRP是影响血清OC水平的独立危险因素(P<0.05)。结论在老年T2DM病人中,慢性炎症指标可能与血清OC水平有一定的相关性。

Objective To investigate the relationship between serum osteocalcin(OC) level and chronic inflammation in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 192 patients in our hospital from June 2018 to March 2020 were enrolled,including 92 patients with T2DM and 100 patients with non-T2DM.The serum OC level and general biochemical indicators as well as chronic inflammation were compared between the two groups.In T2DM groups,the relationship between serum OC level and chronic inflammation were also analyzed.Results Serum OC level in elderly T2DM patients was lower than that in the non-T2DM group[(10.46±4.02) ng/mL vs.(15.76±5.81)ng/mL,P<0.01],while the FPG,HBA1C,serum ferritin(SF),Hs-CRP and monocyte count was higher than that in the non-T2DM group[(10.05±3.48)mmol/l vs.(5.18±0.70)mmol/l,(8.18±1.47)% vs.(5.51±0.31)%,(7.24±0.57)mmol/L vs.(5.46±0.29)mmol/L,(224.09±190.01)ng/mL vs.(146.06±133.01)ng/mL,(2.71±0.97)mmol/l vs.(2.10±0.76)mmol/l,(0.42±0.16) ×10^(9)/L vs.(0.37±0.12)×10^(9)/L,P<0.01].In elderly patients with T2DM,There was a negatively correlation between serum OC level and SF、Hs-CRP and eosinophil count.In addition,serum OC level was independently correlated with SF and Hs-CRP(P<0.05).Conclusion Serum OC level in elderly T2DM patients may be associated with chronic inflammation parameters.