大连市成年人静息心率与代谢综合征的关系

Association between resting heart rate and metabolic syndrome in adults in Dalian

目的探究大连市成年人静息心率(resting heart rate,RHR)与代谢综合征(metabolic syndrome,MS)之间的关系。方法选取2015年1月1日―2017年12月31日在辽宁省大连市大连医科大学附属医院体检中心体检的人员作为研究对象,采用χ^(2)检验对不同心率组间MS患病率进行比较。利用二元Logistic回归分析模型分析RHR与MS之间的关系。结果共纳入研究对象65745例,其中男性36356例,占比55.3%,女性29389例,占比44.7%。Logistic回归分析模型分析结果表明,在校正年龄、身高、体重后,RHR每增加10次/min,全人群的MS患病风险会增加16%(OR=1.16,95%CI:1.13~1.20)。与RHR<70次/min的研究对象相比,RHR≥90次/min的研究对象中男性(OR=1.51,95%CI:1.34~1.71)和女性(OR=1.89,95%CI:1.49~2.40)都有着更高的MS患病风险;此外,与正常BMI(<24 kg/m2)、正常RHR(<80次/min)的研究对象相比,高BMI且高RHR者中女性(OR=14.87,95%CI:11.18~19.77)和男性(OR=6.22,95%CI:5.40~7.17)都有着更高的MS患病风险。结论本研究发现,随着RHR的加快,MS的患病率逐渐上升。此外,RHR和BMI结合应用可以增加RHR作为MS标志物的效力,RHR可以与BMI联合作为一个潜在的临床测量指标。

Objective Investigate the intrinsic relationship between resting heart rate(RHR)and metabolic syndrome(MS).Methods In this study,people who had physical examination in the Physical Examination Center of Dalian Medical University Affiliated Hospital of Dalian City,Liaoning Province from January 1,2015 to December 31,2017 were selected as the study subjects.The prevalence of MS among groups with different heart rates was compared by chi-square test.Binary Logistic regression analysis model was used to analyze the relationship between RHR and MS.Results 65745 subjects were included in the study,including 36356 males(55.3%)and 29389 females(44.7%).Logistic regression analysis showed that after adjusting for age,height and weight,the risk of MS increased by 16%for every 10 increase in RHR per minute(OR=1.16,95%CI:1.13-1.20).Compared with subjects with a RHR of<70 bpm,subjects with a RHR of≥90 bpm had higher odds of MS:1.51(OR=1.51,95%CI:1.34-1.71)in males and 1.89(OR=1.89,95%CI:1.49-2.40)in females.In addition,compared with subjects with normal body mass index(BMI)(<24 kg/m2)and normal RHR(<80 bpm),subjects with high BMI and high RHR had higher odds of MS:14.87(OR=14.87,95%CI:11.18-19.77)in females and 6.22(OR=6.22,95%CI:5.40-7.17)in males.Conclusion In this study,the prevalence of metabolic syndrome was found to increase with increased resting heart rate.In addition,combining RHR and BMI can increase the efficacy of RHR as a marker of metabolic syndrome,and RHR can be combined with BMI as a potential clinical measure indicator.