Paeonol regulates bile acid metabolism in ApoE^(-/-) mice and reduces atherosclerosis

Objective To explore the effect of paeonol(Pae)on the FXR-FGF15 signaling pathway by regulating the metabolism of bile acids in ApoE mice,thereby affecting lipid metabolism to play an anti-atherosclerotic effect.Methods ApoE^(-/-) mice were fed with high-fat diet for 20 weeks to establish an atherosclerotic plaque model,and the model was created and injected with paeonol(200 mg/kg).