PCT、BDNF和HMGB1在热性惊厥患儿中的表达及其与病情严重程度的相关性

Expressions of PCT,BDNF and HMGB1 in Children with Febrile Convulsion and Their Correlations with Severity of the Disease

目的探讨降钙素原(PCT)、脑源性神经营养因子(BDNF)和高迁移率族蛋白B1(HMGB1)在热性惊厥患儿中的表达及其与病情严重程度的相关性。方法选取2019年6月-2020年6月收治的热性惊厥患儿90例作为热性惊厥组,另选取同期体检健康儿60例作为健康对照组。此外,根据相关诊断标准将热性惊厥患儿90例分为单纯组(54例)和复杂组(36例)两组。比较热性惊厥组和健康对照组及单纯组、复杂组和健康对照组PCT、BDNF和HMGB1水平,分析热性惊厥患儿PCT、BDNF和HMGB1水平间的相关性,探讨PCT、BDNF和HMGB1水平与热性惊厥患儿病情严重程度的相关性。结果热性惊厥组PCT、BDNF和HMGB1水平均高于健康对照组,差异有统计学意义(P<0.01)。单纯组、复杂组和健康对照组PCT、BDNF和HMGB1水平总体比较差异均有统计学意义(P<0.01)。PCT、BDNF和HMGB1水平单纯组和复杂组均高于健康对照组,且单纯组低于复杂组,差异具有统计学意义(P<0.01)。Pearson相关性分析结果显示,热性惊厥患儿PCT水平与BDNF、HMGB1水平呈正相关,BDNF水平与HMGB1水平亦呈正相关;PCT、BDNF和HMGB1水平与热性惊厥患儿病情严重程度均呈正相关(P<0.05或P<0.01)。结论PCT、BDNF和HMGB1在热性惊厥患儿中均呈高表达,且其相互之间及与热性惊厥患儿病情严重程度均呈正相关。

Objective To analyze expressions of procalcitonin(PCT),brain-derived neurotrophic factor(BDNF)and high mobility group protein B1(HMGB1)in children with febrile convulsion and their correlations with severity of the disease.Methods Ninety children with febrile convulsion admitted between June 2019 and June 2020 were selected as febrile convulsion group,and other 60 healthy children who had undergone physical examinations at the same period were selected as healthy control group.The 90 children with febrile convulsion were divided into simple subgroup(n=54)and complex subgroup(n=36)according to relevant diagnostic criteria.PCT,BDNF and HMGB1 levels were compared between febrile convulsion and healthy control groups and among simple subgroup,complex subgroup and healthy control group,and the correlations among PCT,BDNF and HMGB1 levels in children with febrile convulsion were analyzed.Correlations between PCT,BDNF and HMGB1 levels with severity of the disease in children with febrile convulsion were analyzed.Results PCT,BDNF,and HMGB1 levels in febrile convulsion group were significantly higher than those in healthy control group(P<0.01).The overall differences in PCT,BDNF and HMGB1 levels among simple subgroup,complex subgroup and healthy control group were statistically significant(P<0.01).PCT,BDNF and HMGB1 levels in simple and complex subgroups were significantly higher than those in healthy control group,and the levels in simple subgroup were significantly lower than those in complex subgroup(P<0.01).Results of Pearson correlation analysis showed that PCT level was positively correlated with BDNF and HMGB1 levels,and BDNF level was also positively correlated with HMGB1 level;PCT,BDNF and HMGB1 levels were positively correlated with severity of febrile convulsion in children with febrile convulsion(P<0.05 or P<0.01).Conclusion PCT,BDNF and HMGB1 are all highly expressed in children with febrile convulsion,and they are positively correlated with each other and with severity of the disease in children with febrile convulsion.