肝内巨噬细胞参与肝脏缺血再灌注损伤的机制

Mechanism of macrophages involved in hepatic ischemia-reperfusion injury

肝脏缺血再灌注损伤(IRI)是创伤、休克、肝脏外科手术和肝移植中常见的病理生理现象,涉及多种分子机制,是各种细胞共同作用的结果。严重的肝脏IRI常导致肝功能障碍,甚至肝衰竭。目前关于肝脏IRI机制尚未完全阐明。近年来有研究发现巨噬细胞在肝脏IRI发生发展过程中发挥了重要作用。本文综述近年来关于巨噬细胞在肝脏IRI中的研究进展,以期为后续研究提供思路。

Hepatic ischemia-reperfusion injury(IRI)is a common pathophysiological phenomenon in trauma,shock,liver surgery and liver transplantation.It involves a variety of molecular mechanisms and is the result of the interaction of various cells.Severe liver IRI often leads to liver dysfunction,even liver failure.Until now,the mechanism of liver IRI has not been fully elucidated.In recent years,macrophages have been found to play an important role in liver IRI.This paper aims to summarize the research progress of macrophages in IRI in recent years,and provide some ideas for further research.