氨基酸在抗肿瘤中药有效成分结构修饰中的应用

Application of Amino Acids in Structural Modification of Active Ingredients of Traditional Chinese Medicine with Antitumor Effects

氨基酸作为生物大分子蛋白质的基本组成单位,参与机体物质代谢调控和信息传递等过程。近年来研究发现,利用氨基酸修饰具有抗肿瘤作用的中药有效成分,例如牛蒡子苷元、齐墩果酸、鬼臼毒素、桦木醇和桦木酸等,可以改善中药有效成分的溶解度,提高生物利用度,并提高对肿瘤细胞的靶向性。本文综述了氨基酸修饰抗肿瘤中药有效成分的研究进展及应用。

Amino acids, as the basic constituent units of biological macromolecular proteins, participate in the processes of metabolic regulation and information transmission in the body. In recent years, studies have found that the use of amino acids to modify active ingredients of traditional Chinese medicine with antitumor effects, such as arctigenin, oleanolic acid, podophyllotoxin, betulin, and betulinic acid, can improve the solubility of active ingredients of traditional Chinese medicine, increase bioavailability, and improve the targeting of tumor cells. This article summarizes the research progress and application of amino acid modification of active ingredients in Chinese medicine with antitumor effects.