血清MMP-2、VEGF和IL-17在早期非小细胞肺癌诊断价值及相关关系

Diagnostic value of serum MMP-2,VEGF and IL-17 in early non-small cell lung cancer and their correlation

目的对非小细胞肺癌(NSCLC)患者血清MMP-2、VEGF和IL-17的水平进行检测并分析其相关性。方法以NSCLC患者为研究组,健康体检者为对照组,采用ELISA法,检测研究对象血清MMP-2、VEGF和IL-17水平,并分析其相关性。结果研究组MMP-2、VEGF、IL-17水平均显著高于对照组(P<0.05)。不同性别和不同年龄阶段NSCLC患者血清MMP-2和VEGF水平无明显差异(P>0.05),鳞癌和腺癌患者血清VEGF水平无显著差异(P>0.05),而鳞癌患者血清MMP-2水平显著低于腺癌患者(P<0.05),有淋巴结转移患者MMP-2、VEGF水平均显著高于无淋巴结转移患者(P<0.05),TNM分期为Ⅰ~Ⅱ患者血清MMP-2、VEGF水平显著低于Ⅲ~Ⅳ患者(P<0.05)。不同性别、不同年龄阶段和病理类型NSCLC患者血清IL-17水平无明显差异(P>0.05),有淋巴结转移患者IL-17水平显著高于无淋巴结转移患者(P<0.05),TNM分期为Ⅰ~Ⅱ患者血清IL-17水平显著低于Ⅲ~Ⅳ患者(P<0.05)。NSCLC患者血清MMP-2和IL-17呈正相关关系(r=0.618,P<0.05),VEGF与IL-17呈显著正相关关系(r=0.548,P<0.05)。结论NSCLC患者血清MMP-2、VEGF、IL-17的水平显著升高,且MMP-2、VEGF均与IL-17显著正相关,对NSCLC的早期确诊和治疗有一定的支持作用。

Objective To detect the serum levels of MMP-2,VEGF and IL-17 in patients with non-small cell lung cancer and to analyze their correlations.Methods The patients with non-small cell lung cancer were taken as the study group,and the healthy examiners were taken as the control group.The serum levels of MMP-2,VEGF and IL-17 were detected by ELISA and their correlations were analyzed.Results The levels of MMP-2,VEGF and IL-17 in the study group were significantly higher than those in the control group(P<0.05).There was no significant difference in serum MMP-2 and VEGF levels in NSCLC patients at different genders and at different ages(P>0.05).There was no significant difference in serum VEGF levels in patients with squamous cell carcinoma and adenocarcinoma(P>0.05),while the level of serum MMP-2 in patients with squamous cell carcinoma was significantly lower than that in patients with adenocarcinoma(P<0.05).The levels of MMP-2 and VEGF in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis(P<0.05).In TNM staging,the serum levels of MMP-2 and VEGF in patients with Ⅰ~Ⅱ was significantly lower than those in patients with Ⅲ~Ⅳ(P<0.05).There was no significant difference in serum IL-17 levels in NSCLC patients at different genders,different ages and pathological types(P>0.05),and the level of IL-17 in patients with lymph node metastasis was significantly higher than that without lymph node metastasis(P<0.05).In TNM staging,the serum IL-17 level of patients with Ⅰ~Ⅱ was significantly lower than that of patients with Ⅲ~Ⅳ(P<0.05).There was a positive correlation between serum MMP-2 and IL-17 in patients with NSCLC(r=0.618,P<0.05),and a significant positive correlation between VEGF and IL-17(r=0.548,P<0.05).Conclusion The levels of serum MMP-2,VEGF,and IL-17 in NSCLC patients are significantly increased,and MMP-2 and VEGF are significantly positively correlated with IL-17,which can support the early diagnosis and treatment of NSCLC.