血细胞比值、平均血小板体积评估系统性红斑狼疮活动性研究

Study on evaluating value of neutrophils/lymphocytes,platelets/lymphocytes and average platelet volume for activity of systemic lupus erythematosus

目的:研究中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、平均血小板体积(MPV)评估系统性红斑狼疮(SLE)活动性的价值。方法:选取2018年1月—2020年6月我院治疗的SLE患者109例(SLE组),根据SLE疾病活动指数(SLE-DAI)分为活动组56例,缓解组53例,另选取健康体检人员56例作为对照组,比较SLE组、对照组,活动组、缓解组间NLR、PLR、MPV、C反应蛋白(CRP)、血沉(ESR)、SLE-DAI、补体C3结果差异,并进行统计分析。结果:SLE组NLR、PLR、MPV、CRP、ESR均高于对照组,补体C3低于对照组(P<0.05);活动组、缓解组、对照组检测指标两两比较差异均有统计学意义(均P<0.05);NLR、PLR、MPV与SLE-DAI均呈正相关,r值分别为0.32、0.19、0.27;NLR、PLR、MPV评估活动性SLE AUC面积分别为0.747、0.696、0.701,最佳截断值分别为4.55、172.51、10.56,纠正混杂因素后,NLR、PLR、MPV均为活动性SLE影响因素,OR分别为2.16、1.45、1.65(P<0.05),根据截断值分层后NLR、PLR、MPV均为活动性SLE影响因素,OR分别为3.51、1.76、2.87(均P<0.05),活动性SLE治疗前后观察指标差异有统计学意义(P<0.05)。结论:NLR、PLR、MPV检测简单、快速,对活动性SLE评估和治疗效果评价具有一定的价值,适合在基层医疗机构推广应用。

Objective:To study on evaluating the value of neutrophils/lymphocytes,platelets/lymphocytes and average platelet volume for the activity of systemic lupus erythematosus(SLE).Methods:From January 2018 to June 2020,109 SLE patients treated in our hospital were divided into active group 56 cases,non-active group 53 cases,and 56 cases of healthy persons were selected as control group.Compare the results of NLR,PLR,MPV,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),SLE-DAI,and complement C3 between the control group,the active group and the inactive group,and the data were stati;stically analyzed.Results:The NLR,PLR,MPV,CRP,ESR in SLE group were higher than those in control group,while complement C3 in SLE group was lower than that in control group(P<0.05),and the differences in the detection indicators of the active group,inactive group,and control group were statistically significant(all P<0.05),NLR,PLR,MPV and SLE-DAI were all positively correlated,with r values were 0.32,0.19 and 0.27,respectively.NLR,PLR,and MPV assess active SLE AUC areas were 0.747,0.696 and 0.701,respectively,and the best cut-off values were 4.55,172.51 and 10.56,respectively.After correcting the confounding factors,NLR,PLR,and MPV were all influencing factors of active SLE,with OR values were 2.16,1.45,and 1.65 respectively(all P<0.05).According to the cut-off values,NLR,PLR,and MPV were all influencing factors of active SLE,with OR values were 3.51,1.76,and 2.87(all P<0.05).The differences in the observation indexes before and after active SLE treatment were statistically significant(all P<0.05).Conclusion:The detection of NLR,PLR,and MPV might be simple and fast,and have certain value for the evaluation of active SLE and the evaluation of treatment effect,and be suitable for popularization and application in primary medical institutions.