文拉法辛和艾司西酞普兰对抑郁症患者的临床疗效

Clinical Efficacy of Venlafaxine and Escitalopram in Patients With Depression

目的分析对抑郁症患者在治疗时应用艾司西酞普兰、文拉法辛的临床价值。方法选取病例时间为2018年1月1日—2019年12月31日,选取80例抑郁症患者,分为应用对照组采用文拉法辛(n=40),试验组采用艾司西酞普兰(n=40),评价用药疗效,并对患者心率变异性及自主神经功能的影响进行分析。结果试验组总有效治疗率与对照组相比,差异无统计学意义(P>0.05);但试验组SDNN、PNN50和SDANN等心率变异分析系统指标优于对照组(P<0.05);且试验组患者交感神经皮肤反应起始波潜伏期和波幅相比于对照组更佳(P<0.05)。结论对抑郁症患者应用文拉法辛和艾司西酞普兰对改善患者心率变异性和自主神经功能具有良好的效果。

Objective To analyze the clinical value of escitalopram and venafaxine in patients with depression.Methods The cases from 1 January 2018 to 31 December 2019 to 80 depression patients treated in our hospital were divided into n=40 and n=40(escitalopram)to evaluate the efficacy and analyze the effects of heart rate variability and autonomic nerve function.Results The total effective rate of the control group(P>0.05);but the heart rate variation systems such as SDNN,PNN50 and SDANN were significantly better than the control group(P<0.05)and that of the control group(P<0.05).Conclusion The application of venafaxine and escitalopram improves depression scores,but escitalopram has good effect on improving the heart rate variability and autonomic nerve function.