超敏C反应蛋白与新发脑出血关系研究

Relationship between Hypersensitive C-reaction Protein and Intracerebral Hemorrhage

目的探讨超hs-CRP水平与新发脑出血事件的相关性。方法连续纳入2006年6月-2007年10月开滦社区的体检者,基线期完善问卷调查、体格检查及实验室检查。每24个月对受检者进行一次面对面随访,截至2017年12月31日,记录所有受检者随访期间新发脑出血事件类型及时间,按照是否出现新发脑出血事件分为新发脑出血组及对照组。将两组基线期一般临床资料、既往病史、体检结果、hs-CRP等实验室检查结果进行比较,采用Cox比例风险回归模型评估hs-CRP水平对新发脑出血事件的影响,同时进一步分析不同性别人群中hs-CRP对新发脑出血事件的影响。结果研究共纳入受试者87242人,随访期间出现新发脑出血事件者829人。Cox比例风险回归模型分析发现,高hs-CRP水平是女性人群中新发脑出血的独立危险因素(HR 1.199,95%CI 1.040~1.383,P=0.0125)。结论高hs-CRP水平可能会增加脑出血事件的发生风险,尤其在女性人群中更应引起关注。

Objective To investigate the relationship between hs-CRP level and intracerebral hemorrhage(ICH).Methods This study enrolled the participants from June 2006 to October 2007 in Kailuan study,and all the subjects finished the questionnaire,physical examination and laboratory examinations at the baseline.The face-to-face follow-up were conducted every two years.The new ICH events during the follow-up were recorded until December 31,2017,and the subjects were divided to new ICH group and control group according to ICH occurring or not.The baseline data including hsCRP level between the two groups were compared.Cox regression analysis was used to analyze the effect of hs-CRP level on new ICH event.The effect of hs-CRP level on the new ICH event in different gender sub-groups was analyzed as well.Results A total of 87242 participants were finally included in this study,and new ICH event occurred in 829 participants.Cox regression analysis showed that high hs-CRP level was an independent risk factor for ICH in women subgroup(HR 1.199,95%CI 1.040-1.383,P=0.0125).Conclusions High hs-CRP level may increase the risk of ICH event,especially in women.