转录因子在肝癌中调节作用的研究进展

Advances in Regulation of Transcription Factors in Liver Cancer

肝癌是世界上最常见的恶性肿瘤之一,由于预后不良而具有较高死亡率,其中,肝细胞癌(hepatocellular carcinoma,HCC)是肝癌最常见的类型。转录因子是在细胞转录过程中通过与基因启动子DNA序列结合而影响靶基因表达的调节因子。研究表明,转录因子通过多种方式调节肝癌发生发展的各个方面,起着重要的作用。本文主要围绕转录因子在肝癌发生发展相关过程的功能和作用进行总结与展望,包括引发肝癌的病毒感染过程,肝癌细胞的增殖、凋亡、转移和活力,以及作为肝癌治疗和预后的生物标记物等多个方面。

Liver cancer is one of the most common malignant tumors in the world and has a high mortality rate due to poor prognosis.Hepatocellular carcinoma(HCC)is the most common type of liver cancer.Transcription factors are regulatory factors that regulate expressions of target genes by binding to target gene promoters during cellular transcription.Transcription factors can regulate various aspects of liver cancer in a variety of ways.The regulatory roles of transcription factors in related processes of HCC initiation and development are summarized,including virus infection,cell proliferation,apoptosis,metastasis and viability,and acting as biomarkers for diagnosis and therapy of liver cancer.