哺乳动物毛囊周期性生长调控机制的研究进展

Advances in Regulatory Mechanisms of Mammalian Hair Follicle Periodic Growth

毛囊是哺乳动物特有的皮肤附属器官,循环经历着生长期、退行期和休止期,每个时期都受一系列基因及其他相关因子的调控。目前,关于毛囊生长发育及调控机制的研究取得了较大的进展,尤其是在毛囊干细胞的活化、增殖、分化方面。本文简要介绍了毛囊的周期性生长过程,概括了褪黑素及毛囊相关基因和信号通路在毛囊上的研究进展,阐述了非编码RNA和其他相关蛋白质/细胞对毛囊周期性生长的调控机制,期望能够为构建毛囊生长发育的分子调控网络及深入探讨毛囊周期性生长的调控机制提供借鉴,为利用现代分子生物技术改善毛用动物绒/毛的品质提供理论依据。

The hair follicle is a particular skin appendage organ of mammals and undergoes the cycle of anagen,catagen,and telogen,which is regulated by a series of genes and other related factors.Now,great progress has been achieved in research on the growth,development and regulation mechanisms of hair folli-cles,especially activation,proliferation and differentiation of hair follicle stem cells.Herein,the periodic growth of hair follicles was introduced,and the research progresses of melatonin,hair follicle-related genes and signaling pathways were summarized.The regulation mechanisms of non-coding RNA and other related proteins/cells involved in hair follicle periodic growth were also concluded.The review provides reference for constructing molecular regulatory network of hair follicle growth and development and for further studying regulation mechanisms of periodic hair follicle growth.It also provides theoretical basis for using modern molecular biotechnology to improve the quality of animal wool/hair.