肿瘤电场治疗在实体肿瘤中的研究进展

Research progress of tumor treating fields therapy in solid tumors

目的总结肿瘤电场治疗(TTFields)在实体肿瘤治疗方面的研究进展。方法应用PubMed、中国知网及万方期刊全文数据库检索系统,以“肿瘤电场治疗(TTFields)、癌(cancer)、胶质瘤(glioma)”为关键词,检索2001年2月-2021年2月发表的TTFields相关文献共103篇。纳入标准:TTFields治疗的作用机制、临床应用及毒性管理;排除标准:重复类文献和低质量类文献。最终纳入文献38篇。结果TTFields通过在肿瘤区域提供低强度中频交变电场,达到抑制肿瘤细胞有丝分裂,从而杀死肿瘤细胞的目的。TTFields在胶质母细胞瘤和恶性胸膜间皮瘤中应用最为广泛,疗效确切,毒副作用轻,被众多指南和规范推荐;在其他实体瘤中大多正进行Ⅱ~Ⅲ期的临床试验,包括非小细胞肺癌、肝癌、胃癌、胰腺癌和卵巢癌等。结论TTFields是一种新兴的非侵入性肿瘤治疗方法,疗效确切,毒副作用轻,尤其在脑胶质瘤中值得推广,期待更多临床试验结果指导实体肿瘤治疗。

Objective To review the research progress of tumor treating fields(TTFields)in the treatment of solid tumors.Methods PubMed,CNKI and Wanfang periodical full-text database retrieval system were used to search the related articles about TTFields published from 2001-02 to 2021-02 with"TTFields,cancer,glioma"as keywords.A total of 103 articles related to TTFields have been searched.Inclusion criteria:the mechanism of action,clinical application and toxicity management of TTFields.Exclusion criteria:duplicate literature and low-quality literature,and 38 articles were finally included.Results TTFields could inhibit the mitosis of tumor cells and kill tumor cells by providing low intensity intermediate frequency alternating electric field in the tumor area.TTFields was the most widely used in glioblastoma and malignant pleural mesothelioma,with definite efficacy and mild side effects,so it was recommended by many guidelines and norms.Ⅱ-Ⅲphase clinical trials were being carried out in other solid tumors,including non-small cell lung cancer,liver cancer,gastric cancer,pancreatic cancer,ovarian cancer,etc.Conclusions TTFields is a new non-invasive tumor therapy with definite efficacy and mild side effects,especially in gliomas.We look forward to moreⅢclinical trial results to guide the treatment.