胺碘酮注射液治疗急性心力衰竭并快速心律失常的临床效果

Clinical effect of Amiodarone Injection in the treatment of acute heart failure and tachyarrhythmia

目的分析胺碘酮注射液治疗急性心力衰竭并快速心律失常的临床效果。方法选取2018年10月—2020年10月贵州医科大学附属白云医院心内科收治的70例急性心力衰竭合并快速心律失常患者作为研究对象,按照随机数字表法分为研究组和对比组,每组各35例。对比组采用常规治疗,研究组采用胺碘酮注射液,比较两组的综合有效率以及治疗前后体征指标[舒张压(DBP)、收缩压(SBP)、平均动脉压(MAP)、心率(HR)]、动态心动图指标[校正后QT间期(QTc)、QT离散度(QTd)]、心功能指标[左室收缩期内径(LVDS)、左室舒张期内径(LVDD)、左心室功能(LVEF)、心指数(CI)、6 min步行距离]。结果研究组的综合有效率高于对比组,差异有统计学意义(P<0.05)。治疗后,研究组的SBP、MAP、HR均低于对比组,DBP高于对比组,差异有统计学意义(P<0.05)。治疗后,研究组的QTc高于对比组,QTd低于对比组,差异有统计学意义(P<0.05)。研究组治疗后的LVEF、CI高于对比组,6 min步行距离值大于对比组,差异有统计学意义(P<0.05)。治疗后,研究组的LVDS、LVDD低于对比组,差异有统计学意义(P<0.05)。结论在急性心力衰竭并快速心律失常患者临床治疗中加用胺碘酮注射液,可发挥协同作用,提高治疗有效率,同时也能够更好改善体征指标、动态心动图指标以及心功能,整体治疗效果可观。

Objective To analyze the clinical effect of Amiodarone Injection in the treatment of acute heart failure and tachyarrhythmia.Methods A total of 70 patients with acute heart failure complicated with tachyarrhythmia admitted to the Department of Cardiology,Baiyun Hospital Affiliated to Guizhou Medical University from October 2018 to October 2020 were selected as the research subjects.According to the random number table method,they were divided into study group and control group,with 35 patients in each group.The control group was treated with routine treatment and the study group was treated with Amiodarone Injection.The comprehensive effectiveness rate and physical indicators before and after treatment including diastolic blood pressure(DBP),systolic blood pressure(SBP),mean arterial pressure(MAP),heart rate(HR),and dynamic echocardiographic indicators including corrected QT interval(QTc)and QT dispersion(QTd),and cardiac function indicators including left ventricular systolic dimension(LVDS),left ventricular diastolic diameter(LVDD),left ventricular function(LVEF),cardiac index(CI),and 6-min walking distance of the two groups were compared.Results The comprehensive effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,SBP,MAP and HR in the study group were lower than those in the control group,while DBP was higher than those in the control group,with statistical significance(P<0.05).After treatment,QTC of the study group was higher than that of the control group,and QTD of the study group was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the LVEF and CI of the study group were higher than those of the control group,and the 6-min walking distance was greate than that of the control group,with statistical significance(P<0.05).After treatment,LVDS and LVDD in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The addition of Amiodarone Injection in the clinical treatment of patients with acute heart failure and tachyarrhythmia can exert a synergistic effect and enhance the treatment effectiveness.Meanwhile,it can greatly improve the physical indicators,dynamic echocardiographic indicators and cardiac function,with a considerable overall treatment effect.