中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值与风湿免疫性疾病关系的研究进展

Research progress on the relationship between neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and rheumatic immune disease

风湿免疫性疾病发病机制复杂且发病率高,易反复发作,炎症反应在风湿免疫性疾病中起着非常重要的作用。国内外研究者近年发现中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)这两个炎症指标,易于测量,可快速重现,并且比较经济。最初研究表明NLR、PLR与心血管疾病或恶性肿瘤患者疾病活动和预后有关,近年研究发现NLR、PLR与风湿免疫性疾病的急性期活动性也有关,并可预测风湿免疫性疾病相关并发症的风险。本文就NLR、PLR与风湿免疫性疾病关系的研究进展作相关综述。

The pathogenesis of rheumatic immune diseases is complicated and the incidence is high,and it is easy to recur.Inflammatory response plays a very important role in rheumatic immune diseases.In recent years,researchers at home and abroad have discovered two inflammatory indicators:neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR),which are easy to measure,fast to reproduce,and relatively economical.Initial studies have shown that NLR and PLR are related to the disease activity and prognosis in patients with cardiovascular diseases or malignant tumors.Recent studies have found that NLR and PLR are related to the acute phase activity of rheumatic immune diseases and can predict the risk of complications related to rheumatic immune diseases.This article reviews the research progress of NLR、PLR and rheumatic immune disease.