新辅助同步放化疗治疗局部晚期直肠癌的临床效果

Clinical effect of neoadjuvant concurrent radiotherapy and chemotherapy in the treatment of locally advanced rectal cancer

目的探讨新辅助同步放化疗治疗局部晚期直肠癌的临床效果。方法选取鞍山市肿瘤医院2019年1月—2020年1月收治的82例局部晚期直肠癌患者作为研究对象,按照随机数字表法分为单纯放疗组(41例)与新辅助同步放化疗组(41例)。单纯放疗组采用单纯放疗方法,新辅助同步放化疗组采用新辅助同步放化疗方法。比较两组的病情控制优良率、不良反应发生率。结果新辅助同步放化疗组的病情控制优良率高于单纯放疗组,差异有统计学意义(P<0.05);两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论新新辅助同步放化疗治疗局部晚期直肠癌的临床效果更加显著。

Objective To investigate the clinical effect of neoadjuvant concurrent radiotherapy and chemotherapy in the treatment of locally advanced rectal cancer.Methods A total of 82 patients with locally advanced rectal cancer admitted to Anshan Cancer Hospital from January 2019 to January 2020 were selected as the research objects,and were divided into radiotherapy alone group(41 cases)and neoadjuvant concurrent radiotherapy and chemotherapy group according to the random number table method(41 cases).The radiotherapy alone group was treated with radiotherapy alone,neoadjuvant concurrent radiotherapy and chemotherapy group was treated with neoadjuvant concurrent radiotherapy and chemotherapy.The two groups disease control excellent and good rate and adverse reaction rate were compared.Results The rate of good condition control in the neoadjuvant concurrent radiotherapy group was higher than that of the radiotherapy group alone,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of neoadjuvant concurrent radiotherapy and chemotherapy for locally advanced rectal cancer is more significant.