特布他林联合丙酸倍氯米松/布地奈德治疗轻、中度哮喘患儿急性发作的效果比较

Effect comparison of Terbutaline combined with Beclomethasone Propionate/Budesonide in the treatment of acute attack of mild to moderate asthma in children

目的探讨丙酸倍氯米松或布地奈德联合特布他林治疗轻、中度哮喘患儿急性发作的临床效果。方法选取2019年1月—2020年4月湖北省松滋市人民医院收治的100例轻、中度哮喘急性发作患儿作为研究对象,根据随机数字表法将其分为对照组与观察组,每组各50例。对照组患儿给予布地奈德联合特布他林治疗,观察组患儿给予丙酸倍氯米松联合特布他林治疗。治疗7 d后,比较两组患儿的临床疗效、症状消失时间、住院时间、症状评分、肺功能指标及不良反应发生情况。结果治疗7 d后,两组患儿的总有效率比较,差异无统计学意义(P>0.05);两组患儿的咳嗽、呼吸困难、肺部哮鸣音消失时间以及住院时间比较,差异无统计学意义(P>0.05);两组患儿的夜间及日间症状评分比较,差异无统计学意义(P>0.05);两组患儿的第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)比较,差异无统计学意义(P>0.05);两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。结论丙酸倍氯米松或布地奈德联合特布他林治疗轻、中度哮喘患儿急性发作的效果相当,均可有效改善患儿的临床症状和肺功能,且均未见明显不良反应,值得临床推广应用。

Objective To investigate the clinical effect of Beclomethasone Propionate and Budesonide with Terbutaline in treatment of mild to moderate childhood asthma exacerbations.Methods A total of 100 children with mild to moderate asthma acute attack admitted to People′s Hospital of Songzi City from January 2019 to April 2020 were selected as the research objects.According to the random number table method,they were divided into the control group and the observation group,with 50 cases in each group.The control group was given Budesonide combined with Terbutaline,and the observation group was given Beclomethasone Propionate combined with Terbutaline.After 7 days of treatment,the clinical efficacy,symptom disappearance time,hospital stay,symptom score,pulmonary function indexes and the incidence of adverse reactions were compared between the two groups.Results After 7 days of treatment,there was no statistically significant difference in the total effective rate between the two groups(P>0.05).There were no statistically significant differences in cough,dyspnea,pulmonary wheezing,disappearance time and hospitalization time between the two groups(P>0.05).There were no statistically significant differences in nocturnal and daytime symptom scores between the two groups(P>0.05).There were no statistically significant differences in 1 second forced expiratory volume(FEV1),FEV1/forced vital capacity(FVC)between the two groups(P>0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of Beclomethasone Propionate and Budesonide with Terbutaline in treatment of mild to moderate childhood asthma exacerbations are similar,can effectively improve the clinical symptoms,signs and lung function of the children,and there is no increase in adverse reactions,it is worthy of promotion and application.