血清胎盘生长因子联合多普勒超声在预测子痫前期的价值分析

Value and its analysis of serum placental growth factor combined with Doppler ultrasonography in predicting preeclampsia

目的研究孕妇血清胎盘生长因子(PLGF)联合多普勒超声在预测子痫前期中的价值。方法选择常规产前检查并确诊妊娠期高血压疾病的孕妇,分为子痫前期组82例、妊娠高血压组85例、对照组170例。检测PLGF水平、子宫动脉搏动指数(PI)、阻力指数(RI)。计算上述指标对子痫前期诊断的灵敏度和特异度。结果 3组孕妇孕15周~20周血清PLGF比较,差异均无统计学意义(P>0.05)。孕24周~28周血清PLGF,3组比较差异均有统计学意义(P<0.05)。孕20周~24周,子痫前期组的PI和RI值均高于妊娠期高血压组及对照组(P<0.05)。PLGF、子宫动脉搏动指数PI、阻力指数RI预测子痫前期的ROC曲线下面积分别为0.862、0.905、0.910。3个指标并联预测子痫前期的灵敏度为94.3%,特异度为63.4%,串联灵敏度为62.1%,特异度为95.8%。结论孕妇血清PLGF联合多普勒超声在预测子痫前期中具有较好的临床价值。

Objective To study the value of serum placental growth factor(PLGF) combined with Doppler ultrasonography in the prediction of preeclampsia in pregnant women(PE).Methods Pregnant women diagnosed with preeclampsia were divided into preeclampsia group(n=82),preeclampsia group(n=85) and control group(n=170).PLGF level,uterine arterial pulse index(PI) and resistance index(RI) were detected.The sensitivity and specificity of the above indicators for the diagnosis of preeclampsia were calculated.Results There was no statistical significance on the difference in serum PLGF between the three groups from 15 to 20 weeks of pregnancy(P>0.05).There was statistical significance between the three groups in the differences of serum PLGF from 24 to 28 weeks of pregnancy(P<0.05).From 20 to 24 weeks of gestation,PI and RI values in preeclampsia group were higher than those in gestational hypertension group and control group(P<0.05).The area under the ROC curve of preeclampsia predicted by PLGF,uterine artery pulse index PI and resistance index RI were 0.862,0.905 and 0.910,respectively.The sensitivity and specificity for predicting preeclampsia were 94.3% and 63.4% in parallel,and 62.1% and 95.8% in series.Conclusion Serum PLGF combined with Doppler ultrasound in pregnant women has good clinical value in the prediction of preeclampsia.