2型糖尿病肾病的临床生化指标变化特征和危险因素分析

Analysis of clinical biochemical characteristics and risk factors of 2 diabetic nephropathy

目的分析2型糖尿病发生糖尿病肾病(DN)的临床生化指标变化特征,寻找DN的危险因素。方法选择该院2015年9月至2019年5月收治的209例2型糖尿病患者为研究对象,根据有无DN分为DN组和非糖尿病肾病(non-DN)组,比较两组临床指标的变化。结果与non-DN组相比,DN组多项临床指标水平明显异常。二元Logistic回归分析,发现血压、体质量指数(BMI)、尿素氮(BUN)、血清肌酐(Scr)、唾液酸(SA)、补体C1q是DN的危险因素。ROC曲线分析发现C1q对于DN的预测有很好的参考价值。结论糖尿病患者在控制血糖的同时应控制好血压和体质量,关注C1q和肾功能指标变化可以尽早发现DN。

Objective To investigate the characterization of clinical biochemical parameters in diabetic nephropathy(DN)and to find out the risk factors of DN.Methods Two hundred and nine patients with type 2 diabetes(T2D)from September 2015 to May 2019 were enrolled and classified into DN group and non-DN group.Compared the basic characteristics between the two groups and assessed which was a risk factor of DN.Results Compared with non DN group,the levels of several clinical indexes in DN group were significantly abnormal.Binary Logistic regression analysis showed that blood pressure,body mass index(BMI),urea nitrogen(BUN),serum creatinine(Scr),sialic acid(SA)and complement C1q were risk factors for DN.ROC curve analysis showed that C1q has a good reference value for DN prediction.Conclusion Diabetic patients should control blood pressure and body weight while controlling blood glucose,and pay attention to the changes of C1q and renal function indexes,so as to find DN as soon as possible.