基于阶梯乳化的微流控技术在医学领域中的应用

Application of microfluidic technology based on step emulsification in medical field

微流控技术因成本低、样品量小、分析时间短、高灵敏度和易于自动化等优点,已广泛用于分子检测、成像、药物输送、诊断以及细胞生物学等众多领域中。液滴技术是微流控技术的重要分支,其中基于阶梯乳化的微流控技术,由于液滴直径对分散相和连续相的流速和流体特性不敏感,对流体控制要求低,现在不仅仅在生产单分散液滴领域,如分子检测、耐药性检测中发挥作用,也越来越多的在生产高单分散性和稳定质量的微胶囊和微凝胶等材料中扮演重要角色。本文主要介绍阶梯乳化在医学领域中的应用,以及探讨其存在的挑战和未来的发展。

Microfluidic technology has been widely used in many fields such as molecular detection,imaging,drug delivery,diagnosis and cell biology due to its advantages of low cost,small sample size,short analysis time,high sensitivity and easy automation.Droplet technology is an important branch of microfluidics technology.Because the droplet diameter is not sensitive to the flow rate and fluid characteristics of dispersed phase and continuous phase,and has low requirements for fluid control,it is not only playing a role in the production of monodisperse droplets,such as molecular detection and drug resistance detection,but also more and more in the production of high monodisperse and stable droplets microcapsules and microgel materials play an important role.This paper mainly introduces the application of step emulsification in the field of medicine,and discusses its existing challenges and future development.