Human coronaviruses and therapeutic drug discovery

Background:Coronaviruses(CoVs)are distributed worldwide and have various susceptible hosts;CoVs infecting humans are called human coronaviruses(HCoVs).Although HCoV-specific drugs are still lacking,many potent targets for drug discovery are being explored,and many vigorously designed clinical trials are being carried out in an orderly manner.The aim of this review was to gain a comprehensive understanding of the current status of drug development against HCoVs,particularly severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).