Nupr1、HE4及AFP表达与卵巢癌病理参数、预后生存的关系

Relationship between the expressions of Nupr1,HE4 and AFP and the pathological parameters,prognosis and survival of ovarian cancer

目的分析核蛋白1(Nupr1)、人附睾蛋白4(HE4)及甲胎蛋白(AFP)与卵巢癌病理参数、预后生存的关系。方法分析2015年1月至2018年12月本院收治的90例卵巢癌和80例卵巢良性病变患者临床资料,分别作为卵巢癌组和良性病变组。比较2组Nupr1、HE4及AFP表达,记录所有卵巢癌患者临床病理特征及预后生存情况,使用Logistic回归模型分析影响卵巢癌患者预后生存的独立危险因素。结果卵巢癌组Nupr1、HE4及AFP阳性表达率均高于良性病变组,差异有统计学意义(P<0.05)。FIGO分期:Ⅲ+Ⅳ期、分化程度:低分化者Nupr1、HE4及AFP阳性表达率均高于FIGO分期:Ⅰ+Ⅱ期、分化程度:中高分化者,差异有统计学意义(P<0.05)。随访2年结果显示:90例卵巢癌患者死亡51例,存活39例,存活率为43.33%。生存组与死亡组两组FIGO分期、组织分化程度、淋巴转移情况及Nupr1、HE4和AFP阳性表达比较差异有统计学意义(P<0.05)。存在淋巴转移、Nupr1、HE4和AFP阳性为影响卵巢癌患者预后生存的独立危险因素(P<0.05)。结论 Nupr1、HE4及AFP在卵巢癌患者中呈高表达状态,三者异常表达与患者临床病理特征及预后生存有密切关系,可作为预测患者预后生存的有效指标。

Objective To analyze the relationships between the expressions of nuclear protein 1(Nupr1),human epidiymis protein 4(HE4) and alpha fetoprotein(AFP),pathological parameters and prognosis survival of patients with ovarian cancer. Methods The clinical data of 90 patients with ovarian cancer and 80 patients with benign ovarian lesions admitted to this hospital from January 2015 to December2018 were analyzed and selected as the ovarian cancer group and the benign lesion group,respectively. The expressions of Nupr1,HE4 and AFP were compared between 2 groups. The clinicopathological features and prognosis survival of all patients with ovarian cancer were recorded,and the logistic regression model was used to analyze the independent risk factors affecting the prognosis survival of patients with ovarian cancer. Results The positive expression rates of Nupr1,HE4 and AFP in the ovarian cancer group were all significantly higher than those in the benign lesion group,and the differences were statistically significant(P<0.05). The positive expression rates of Nupr1,HE4 and AFP in patients who were at Ⅲ + Ⅳ in FIGO staging with lower differentiation were higher than those in patients who were at Ⅰ+Ⅱ in FIGO staging with moderate to higher differentiation,and the differences were statistically significant(P<0.05). The follow-up results showed that in the 90 patients with ovarian cancer,51 died and 39 survived,the survival rate was 43.33%. There were statistically significant differences between the survival group and the death group in FIGO stage,degree of tissue differentiation,lymphatic metastasis,and the positive expression of Nupr1,HE4 and AFP(P<0.05).The presence of lymphatic metastasis and positive Nupr1,HE4 and AFP are independent risk factors affecting the prognosis survival of patients with ovarian cancer(P<0.05). Conclusion Nupr1,HE4 and AFP are highly expressed in patients with ovarian cancer. The abnormal expressions of the three is closely related to the clinical pathological features and prognosis and survival of patients,and can be used as effective indicators for predicting the prognosis survival of patients.