ADAMTs-1、CF6、CARP在冠心病合并慢性心力衰竭中的意义

Significance of ADAMTs-1,CF6 and CARP in coronary heart disease complicated with chronic heart failure

目的:分析Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶(ADAMTs-1)、线粒体耦联因子-6(CF6)、心锚重复蛋白(CARP)在冠心病合并慢性心力衰竭(CHF)中的意义。方法:2017年4月—2020年4月收治90例冠心病合并CHF患者作为研究组,按照美国纽约心脏病学会对心功能进行分级,另分为3个亚组:心功能Ⅱ级组:28例,心功能Ⅲ级组:32例,心功能Ⅳ级组:30例;同时纳入同期接受健康体检者,共52例,作为对照组。收集所有研究对象一般资料,记录ADAMTs-1、CF6、CARP、脑钠肽(BNP)、左室舒张末期内径(LEVDD)、左室射血分数(LVEF)水平。比较研究组与对照组ADAMTs-1、CF6、CARP、BNP、LEVDD、LVEF水平差异及ADAMTs-1、CF6、CARP、BNP、LEVDD、LVEF水平在心功能分级中的表达情况;采用Pearson相关分析分别观察冠心病合并CHF患者ADAMTs-1、CF6及CARP水平与心功能分级的关系。结果:研究组患者ADAMTs-1、CF6、CARP、BNP及LVEDD水平显著高于对照组,而LVEF水平显著低于对照组,差异具有统计学意义(t=15.218、27.004、28.394、35.227、28.164,均P<0.05)。血清ADAMTs-1、CF6、CARP、BNP、LVEDD水平:Ⅳ级组>Ⅲ级组>Ⅱ级组,LVEF:Ⅳ级组<Ⅲ级组<Ⅱ级组,差异均具有统计学意义(F=34.94、68.87、260.62、141.85、1258.53、17.97,均P<0.05)。冠心病合并CHF患者ADAMTs-1、CF6、CARP水平与BNP、LVEDD呈正相关(均P<0.05),与LVEF呈负相关(P<0.05)。结论:ADAMTs-1、CF6、CARP水平对冠心病合并CHF患者具有重要意义。

Objective:To analyze the significance of adisintesrin and metalloprotease with thrombospondin type 1 motifs(ADAMTs-1),mitochondrial coupling factor-6(CF6),cardiac ankyrin repeat protein(CARP)in coronary heart disease complicated with chronic heart failure(CHF).Methods:The 90 patients with coronary heart disease and CHF admitted to this hospital were selected as the study group from April 2017 to April 2020.The cardiac function was graded according to the New York Society of Cardiology,and divided into three subgroups:28 cases in cardiac function grade Ⅱ group,32 cases in heart function grade Ⅲ group,30 cases in heart function grade Ⅳgroup;at the same time,52 cases were included in the hospital who received normal physical examination results in the same period as the control group.The general data of all research subjects were collected,and ADAMTs-1,CF6,CARP,brain natriuretic peptide(BNP),left ventricular end-diastolic dimension(LEVDD),left ventricular ejection fraction(LVEF)level were recorded.The differences in the levels of ADAMTs-1,CF6,CARP,BNP,LEVDD,LVEF between the study group and the control group were compared,and the expressions of ADAMTs-1,CF6,CARP,BNP,LEVDD,and LVEF levels in cardiac function classification were evaluated.Pearson correlation analysis was used to respectively observe the relationship between the levels of ADAMTs-1,CF6 and CARP in patients with coronary heart disease and CHF and the classification of cardiac function.Results:The levels of ADAMTs-1,CF6,CARP,BNP and LVEDD in the study group were higher than those in the control group,while the LVEF level in the study group was lower than that in the control group,the difference was statistically significant(t=15.218,27.004,28.394,35.227,28.164,all P<0.05).Serum levels of ADAMTs-1,CF6,CARP,BNP,LVEDD:grade Ⅳ group>grade Ⅲ group>grade Ⅱ group,LVEF:grade Ⅳ group<grade Ⅲ group<grade Ⅱ group,the differences were all statistically significant(F=34.94,68.87,260.62,141.85,1258.53,17.97,all P<0.05).The levels of ADAMTs-1,CF6 and CARP in coronary heart disease combined with CHF have positive correlations with BNP and LVEDD,and have egative correlations with LVEF(P<0.05).Conclusion:ADAMTs-1,CF6 and CARP are of great significance to the patients who are with coronary heart disease and CHF.