孟鲁司特钠联合布地奈德鼻喷剂治疗过敏性鼻炎合并支气管哮喘对患者IL-5、IL-13、sVCAM-1的影响

Effects on IL-5,IL-13 and sVCAM-1 in Patients with Allergic Rhinitis and Bronchial Asthma Treated with Montelulast Sodium and Budesonide Nasal Spray

目的:研究孟鲁司特钠联合布地奈德鼻喷剂治疗过敏性鼻炎合并支气管哮喘对患者白介素-5(IL-5)、IL-13、可溶性血管细胞间黏附分子(s VCAM-1)的影响。方法:选取本院2016年8月~2018年12月收治的过敏性鼻炎合并支气管哮喘患者86例,采用随机数字表法分为观察组和对照组,每组43例。对照组给予布地奈德鼻喷剂治疗,观察组给予孟鲁司特钠联合布地奈德鼻喷剂治疗,分析两组患者治疗后的临床效果。结果:观察组总有效率(97.67%)高于对照组(86.05%),具有统计学差异(P <0.05)。治疗后,观察组干扰素γ(IFN-γ)高于对照组(P <0.05);s VCAM-1、可溶性细胞间黏附因子-1(s ICAM-1)、IL-4、IL-5、IL-13低于对照组(P <0.05)。治疗后,观察组ACT评分高于对照组,过敏性鼻炎症状评分低于对照组(P <0.05)。结论:孟鲁司特钠联合布地奈德鼻喷剂治疗过敏性鼻炎合并支气管哮喘可减轻炎症反应,较好地缓解症状,提高治疗效果。

Objective: To study the effects on interleukin-5( IL-5),IL-13 and soluble vascular intercellular adhesion factor( s VCAM-1) in patients with allergic rhinitis and bronchial asthma treated with montelulast sodium and budesonide nasal spray. Methods: 86 patients with allergic rhinitis complicated with bronchial asthma in our hospital( August 2016 to December 2018) were selected and divided into the control group and the observation group by random number method,with 43 cases in each group. The control group was treated with budesonide nasal spray,the observation group was treated with montelulast sodium and budesonide nasal spray,and the clinical effect of 2 groups was analyzed. Results: The total effective rate of the observation group( 97. 67%) was higher than that of the control group( 86. 05%),the difference was statistically significant( P < 0. 05). After treatment,the level of interferon-γ( IFN-γ) in the observation group was higher than that in the control group,s VCAM-1,soluble intercellular adhesion factor-1( s ICAM-1),IL-4,IL-5,IL-13,which was lower than that of the control group( P < 0. 05). After treatment,the ACT score of the observation group was higher than that of the control group,and the sign score of allergic rhinitis was lower than that of the control group( P < 0. 05). Conclusion:Combination of montelulast sodium and budesonide nasal spray in the treatment of allergic rhinitis combined with bronchial asthma can reduce inflammatory response,relieve symptoms and improve the therapeutic effect.