他巴唑联合醋酸泼尼松治疗甲亢的疗效分析

Analysis of the Therapeutic Effect of Methimazole Combined with Prednisone Acetate in the Treatment of Hyperthyroidism

目的探讨他巴唑联合醋酸泼尼松治疗甲亢的临床疗效,为临床用药提供参考。方法选取该院2018年1月—2019年5月就诊的93例甲亢患者为研究对象,依据抽签法分为对照组(n=47)与观察组(n=46)。对照组予以他巴唑口服治疗,观察组于对照组治疗基础上予以醋酸泼尼松口服治疗,比较两组临床疗效、实验室指标及不良反应总发生率。结果观察组总有效率为91.30%较对照组的72.34%高,差异有统计学意义(χ^(2)=5.597,P=0.018);观察组治疗12个月后Ⅲ型前胶原(PCⅢ)为(98.48±13.24)μg/L、β2微球蛋白(β2-MG)为(3.19±1.52)mg/L、透明质酸(HA)为(50.12±6.13)mg/L,均较对照组[(112.34±16.58)μg/L、(4.15±2.13)mg/L、(58.67±7.01)mg/L]降低,观察组白蛋白(ALB)水平(43.25±6.34)g/L,较对照组(37.84±6.03)g/L升高,差异有统计学意义(t=4.449、2.445、6.256、4.217,P<0.05);观察组不良反应总发生率为8.70%较对照组6.38%略高,但差异无统计学意义(χ^(2)=0.179,P=0.673)。结论甲亢患者应用他巴唑联合醋酸泼尼松治疗疗效较佳,可有效改善实验室指标,且安全性较高。

[Objective]To explore the clinical efficacy of methimazole combined with prednisone acetate in the treatment of hyperthyroidism,and to provide references for clinical medication.Methods 93 patients with hyperthyroidism who visited our hospital from January 2018 to May 2019 were selected as the research objects,and were divided into a control group(n=47)and an observation group(n=46)according to the lottery method.The control group was treated with tapazole orally,and the observation group was treated with prednisone acetate based on the treatment of the control group.The clinical efficacy,laboratory indicators and total incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.30%higher than that of the control group 72.34%,the difference was statistically significant(χ^(2)=5.597,P=0.018);the observation group after 12 months of treatment for type Ⅲ procollagen(PCⅢ)was(98.48±13.24)μg/L,β2 microglobulin(β2-MG)was(3.19±1.52)mg/L,and hyaluronic acid(HA)was(50.12±6.13)mg/L,which were all compared with the control group[(112.34±16.58)μg/L,(4.15±2.13)mg/L,(58.67±7.01)mg/L]decreased,and the albumin(ALB)level of the observation group was(43.25±6.34)g/L,compared with the control group(37.84±6.03)g/L increased,the difference was statistically significant(t=4.449,2.445,6.256,4.217,P<0.05);the total incidence of adverse reactions in the observation group was 8.70%slightly higher than that of the control group 6.38%,but the difference was not statistically significant(χ^(2)=0.179,P=0.673).Conclusion The therapeutic effect of methimazole combined with prednisone acetate in patients with hyperthyroidism is better,which can effectively improve laboratory indicators and is safer.