特布他林结合糖皮质激素治疗慢阻肺急性加重期的效果评价

Evaluation of the Effect of Terbutaline Combined with Glucocorticoid in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的分析慢阻肺急性加重期应用特布他林结合糖皮质激素治疗的临床效果。方法该次研究于2018年10月—2019年10月开展,在该院中随机抽选84例患者作为研究样本,记录为参照组与研究组,单组设置样本量为42例。参照组接受特布他林治疗,研究组在参照组的基础上实施糖皮质激素治疗。对比分析治疗前后两组肺功能指标的改善情况及治疗效果,治疗前后两组呼吸功能指标的变化。结果研究发现,治疗后研究组的FEV1(2.54±0.68)、FVC(3.52±0.72)、VC(3.00±0.84)L均优于参照组(2.22±0.60)、(2.93±0.70)、(2.22±0.71)L,差异有统计学意义(t=2.287,P=0.025;t=3.808,P<0.001;t=4.596,P<0.001);研究组总有效率88.09%,高于参照组64.29%,差异有统计学意义(χ^(2)=6.562,P=0.010)。治疗之前,两组呼吸功能指标差异无统计学意义(P>0.05);治疗之后,研究组PaCO2(35.73±3.55)mmHg低于参照组(45.22±3.58)mmHg,且研究组的PaO2为(93.68±3.88)mmHg高于参照组(89.35±3.82)mmHg,差异有统计学意义(t=12.199,P<0.001;t=5.154,P<0.001)。结论对于慢阻肺急性加重期应用糖皮质激素联合特布他林治疗,临床效果更为理想。

Objective To analyze the clinical effect of terbutaline combined with glucocorticoid therapy in the acute exacerbation of chronic obstructive pulmonary disease.Methods The researcht was carried out from October 2018 to October 2019.In the hospital,84 patients were randomly selected as research samples recorded as the reference group and the research group,and the sample was set in a single group.The amount was 42 cases.The reference group received terbutaline treatment,and the study group implemented glucocorticoid therapy on the basis of the reference group.The improvement of lung function indexes of the two groups before and after treatment and the treatment effect were compared and analyzed,and the changes of respiratory function indexes of the two groups before and after treatment were compared.Results The study found that FEV1(2.54±0.68)L,FVC(3.52±0.72)L,VC(3.00±0.84)L of the study group after treatment were better than those of the reference group(2.22±0.60)L,(2.93±0.70)L,(2.22±0.71)L,the difference was statistically significant(t=2.287,P=0.025;t=3.808,P<0.001;t=4.596,P<0.001);the total effective rate of the study group was 88.09%,which was higher than the reference group of 64.29%,the difference was statistically significant(χ^(2)=6.562,P=0.010).Before treatment,there was not statistically significant in respiratory function indexes between the two groups(P>0.05);after treatment,the PaCO2(35.73±3.55)mmHg of the study group was lower than the reference group(45.22±3.58)mmHg,and the PaO2 of the study group was(93.68±3.88)mmHg was higher than the reference group(89.35±3.82)mmHg,the difference was statistically significant(t=12.199,P<0.001;t=5.154,P<0.001).Conclusion The clinical effect of glucocorticoid combined with terbutaline in the acute exacerbation of chronic obstructive pulmonary disease is more ideal.