体检者血清25(OH)D与非酒精性脂肪肝的相关性分析

Correlation Between the Level of Serum 25(OH)D and Nonalcoholic Fatty Liver Disease in Physical Examinees

目的探讨25(OH)D在非酒精性脂肪肝(NAFLD)患者中的特点,分析25(OH)D与NAFL D的相关性。方法选取2018年5月至2018年10月于我院体检中心体检者563名纳入本研究。根据有无NAFLD将受试者分为NAFLD组和对照组(NC组)。所有受试者均进行体格检查和生化指标的测定,比较两组间25(OH)D及所有临床代谢指标的差异。应用Spearman相关分析25(OH)D与各代谢指标的相关性,根据25(OH)D水平四分位数将受试者分为4组,比较组间NAFLD发生率的差异。结果NAFLD组BMI、WC、ALT、AST、GGT、FPG、HOMA-IR、SUA、TC、TG、LDL-C、SBP、DBP水平均高于NC组,差异有统计学意义(P<0.01);NAFLD组25(OH)D及HDL-C水平低于NC组,差异有统计学意义(P<0.01)。Spearma n相关分析显示,NAFLD组25(OH)D与FPG(r=-0.221)、TG(r=-0.250)呈负相关(P均<0.01);25(OH)D与NAFLD呈负相关(r=-0.111,P=0.009)。NAFLD发生率随着25(OH)D水平的升高有下降趋势(P<0.01)。结论NAFLD组25(OH)D水平更低,二者之间具有相关性。

Objective To investigate the characteristics of serum 25(OH)D level in patients with nonalcoholic fatty liver disease(NAFLD),and to analyze the correlation between 25(OH)D and NAFLD.Methods A total of 563 physical examinees who visited the Health Examination Centre of Beijing Shijingshan Hospital for annual physical examination from May 2018 to Oct 2018 were enrolled in this study.According to the presence of NAFLD,they were divided into the NAFLD group and the control group(NC group).All subjects were performed the physical examination and biochemical indexes.The differences of serum 25(OH)D and clinical metabolic indicators between the two groups were compared.Spearman correlation analysis was used to analyze the relationship between serum 25(OH)D and various metabolic indexes.According to the quartile of 25(OH)D level,all subjects were divided into four groups and the incidence of NAFLD were compared among groups.Results The levels of BMI,WC,ALT,AST,GGT,FPG,HOMA-IR,SUA,TC,TG,SBP and DBP in NAFLD group were significantly higher than those in the NC group(P<0.01),while the levels of 25(OH)D and HDL-C in the NAFLD group were significantly lower than those in the NC group(P<0.01).Spearman correlation analysis showed that 25(OH)D level in the NAFLD group were negatively associated with FPG(r=-0.221)and TG(r=-0.250),and were negatively associated with NAFLD in all subjects(r=-0.111,P=0.009).The incidence of NAFLD tended to decrease as the 25(OH)D level increased.Conclusion The level of 25(OH)D was lower in the NAFLD group,and there is a close relationship between 25(OH)D and NAFLD.