超声下射频消融术治疗良性甲状腺结节的效果

Effect of Radiofrequency Ablation Under Ultrasound in the Treatment of Patients with Benign Thyroid Nodules

目的分析超声下射频消融术治疗良性甲状腺结节患者的效果。方法选取周口豫东医院2016年6月至2020年3月收治的110例良性甲状腺结节患者,其中接受开放式甲状腺结节切除术的55例为对照组,55例接受超声下射频消融术治疗的患者为观察组。比较两组术中出血量、手术时间、住院时间、甲状腺功能、肿瘤坏死因子-α(TNF-α)水平、白介素-6(IL-6)水平,以及术后并发症发生率。结果观察组术中出血量较对照组少,手术时间、住院时间较对照组短(P<0.05)。术后7 d观察组促甲状腺激素(TSH)、游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))水平与术前比较,差异无统计学意义(P>0.05);对照组TSH水平高于术前,FT_(4)、FT_(3)水平低于术前(P<0.05);术后7 d,观察组TSH低于对照组,FT_(4)、FT_(3)水平高于对照组(P<0.05)。术后3、7 d两组血清TNF-α、IL-6水平高于术前(P<0.05),观察组血清TNF-α、IL-6水平均低于对照组(P<0.05)。观察组术后并发症发生率与对照组差异无统计学意义(P>0.05)。结论超声下射频消融术治疗良性甲状腺结节整体效果理想,可减少术中出血量,术后机体创伤应激反应较轻,对甲状腺功能影响小,可加快术后康复进程。

Objective To analyze the effect of radiofrequency ablation under ultrasound in the treatment of patients with benign thyroid nodules.Methods A total of 110 patients with benign thyroid nodules admitted to Zhoukou Yudong Hospital from June 2016 to March 2020 were selected.Among them,55 patients who underwent open thyroid nodule resection were selected as control group,and 55 patients who underwent radiofrequency ablation under ultrasound treatment were selected as observation group.The intraoperative blood loss,operation time,hospital stay,thyroid function,tumor necrosis factor-α(TNF-α)level,interleukin-6(IL-6)level,and postoperative complications were compared between the two groups.Results In observation group,intraoperative blood loss was less than that in control group,and the operation time and hospital stay were shorter than those in control group(P<0.05).The levels of thyroid stimulating hormone(TSH),free thyroxine(FT_(4)),and free triiodothyronine(FT_(3))in observation group 7 days after the operation were not statistically different from before(P>0.05).The level of TSH in control group was higher than before,and the levels of FT_(4)and FT_(3)were lower than before(P<0.05).Seven days after the surgery,in observation group,TSH was lower than that in control group,and the levels of FT_(4)and FT_(3)were higher than those in control group(P<0.05).Three and seven days after the operation,the levels of serum TNF-αand IL-6 in the two groups were higher than before(P<0.05),and the levels of serum TNF-αand IL-6 in observation group were lower than those in control group(P<0.05).The incidence of postoperative complications in observation group was not statistically different from that in control group(P>0.05).Conclusion The overall effect of radiofrequency ablation under ultrasound in the treatment of benign thyroid nodules is satisfactory,with less intraoperative blood loss,less postoperative traumatic stress reaction,and less impact on thyroid function,which could speed up the postoperative recovery process.