非小细胞肺癌患者行护士主导下的口服靶向药物治疗对不良反应发生率的研究

Study on the Incidence of Adverse Reaction Rate of Oral Targeted Drug Therapy Leading by Nurses in Patients with Non-small Cell Lung Cancer

目的探讨护士主导下的口服靶向药物治疗非小细胞肺癌患者的不良反应。方法便利选择2018年1月—2020年1月该院收治的90例非小细胞肺癌患者,对其进行随机分组,对照组(n=45)以患者出院时对其进行常规评估与宣教,收集具体的病历资料,叮嘱其出院之后的用药时间、具体剂量及相关注意事项等进行常规护理干预,观察组(n=45)以护士主导下的口服靶向药物管理进行干预,主要方式为加强出院宣教,记录患者的服药执行情况,制定随访计划;做好出院后护理,了解患者的治疗情况,统计分析患者出院之后不同时间内药物事件次数、生活质量评分与不良反应发生率。结果观察组出院后2个月药物事件次数为(0.76±0.24)次、3个月药物事件次数为(0.85±0.29)次、4个月药物事件次数为(0.93±0.28)次、6个月药物事件次数为(0.91±0.31)次,低于对照组,差异有统计学意义(t=11.937、22.801、54.907、75.818,P<0.05);观察组患者不良反应发生率为6.67%,低于对照组,差异有统计学意义(χ^(2)=4.405,P<0.05);观察组患者生活质量评分中心理功能评分为(89.41±7.92)分,躯体功能评分为(91.77±4.63)分,社会功能评分为(93.34±5.96)分,生理功能评分为(95.48±4.91)分,角色功能评分为(86.73±4.20)分高于对照组,差异有统计学意义(t=3.591、3.553、2.454、3.334、3.139,P<0.05)。结论对非小细胞肺癌患者实施护士主导下的口服靶向药物治疗管理效果较好,可提高患者治疗依从性与生活质量,减少药物事件次数,降低用药之后不良反应发生率,临床应用价值较高。

Objective To investigate the adverse effects of nurse-led oral targeted drugs in the treatment of patients with non-small cell lung cancer.Methods Conveniently selected 90 patients with non-small cell lung cancer admitted to the hospital from January 2018 to January 2020.They were randomly divided into groups.The control group(n=45)was routinely evaluated and educated when the patients were discharged from the hospital.Specific medical records,instructed to intervene in routine care such as medication time,specific dosage,and related precautions after discharge.The observation group(n=45)intervened with oral targeted drug management under the guidance of nurses,and the main method was to strengthen discharge propaganda and education,record the patient's medication implementation,develop a follow-up plan;do a good job of post-discharge care,understand the patient's treatment status,and statistically analyze the number of drug events,quality of life scores and adverse reaction rates at different times after the patient is discharged from the hospital.Results The number of drug events in the observation group was(0.76±0.24)times in the second month after discharge from the hospital,the number of drug events in 3 months was(0.85±0.29)times,and the number of drug events in 4 months was(0.93±0.28)times,the number of drug events in 6 months was(0.91±0.31)times lower than the control group,the difference was statistically significant(t=11.937,22.801,54.907,75.818,P<0.05);the incidence of adverse reactions in the observation group was 6.67%lower than the control group,the difference was statistically significant(χ^(2)=4.405,P<0.05);the mental function score in the quality of life score in the observation group was(89.41±7.92)points,and the physical function score was(91.77±4.63)points,social function score was(93.34±5.96)points,physiological function score was(95.48±4.91)points,role function score was(86.73±4.20)points,higher than the control group,the difference was statistically significant(t=3.591,3.553,2.454,3.334,3.139,P<0.05).Conclusion Nurse-led oral targeted drug therapy management for patients with non-small cell lung cancer is effective.It can improve patient compliance and quality of life,reduce the number of drug incidents,and reduce the incidence of adverse reactions after medication.The clinical application value is high.