肝硬化疾病诊断中生化检验项目的临床价值分析

Analysis of the Clinical Value of Biochemical Test Items in the Diagnosis of Liver Cirrhosis

目的探析生化检验项目在肝硬化疾病诊断中的应用价值。方法方便选取2018年1月-2019年12月该院接收的160例肝硬化疾病患者作为研究组,同期另选取到医院行健康体检者160名作为对照组。对所有被选对象行生化检验,比较两者检验后各项生化指标检验结果。结果对照组CHE、ALB和TP水平均高于研究组,差异有统计学意义(P<0.05);研究组γ-GT(177.4±23.0)U/L和AST(96.3±13.2)U/L、ALP(180.4±25.0)U/L和ALT(57.2±10.1)U/L、DBIL(37.1±9.4)μmol/L和TBIL(86.5±8.8)μmol/L高于对照组,差异有统计学意义(t=83.999、75.857、49.051、50.809、45.185、95.472,P<0.05);两组比较,研究组前白蛋白(PA)较低,差异有统计学意义(t=890.688,P<0.05);血清腺苷脱氨酶(ADA)、总胆汁酸(TBA)、透明质酸(HA)、层黏连蛋白(LN),Ⅲ型前胶原(PC-Ⅲ)较高,差异有统计学意义(t=179.919、329.609、285.069、18.122、54.908,P<0.05)。结论由于肝硬化患者伴多种生化指标异常情况,而将生化检验项目用于对肝硬化疾病的诊断中,不但能对早期诊断肝硬化提供数据支持,而且能有效评估患者疾病病情并且判断预后。

Objective To explore the application value of biochemical test items in the diagnosis of liver cirrhosis. Methods From January 2018 to December 2019, 160 patients with cirrhosis in the hospital were conveniently selected as the study group, and 160 patients who went to the hospital for physical examination during the same period were selected as the control group. performing biochemical tests on all selected subjects, the two test results of various biochemical indicators were compared. Results The level CHE, ALB and TP in the control group were higher than those in the study group, and the difference was statistically significant(P<0.05);the study group γ-GT(177.4±23.0) U/L and AST(96.3±13.2)U/L, ALP(180.4±25.0)U/L and ALT(57.2±10.1)U/L, DBIL(37.1±9.4)μmol/L and TBIL(86.5±8.8) μmol/L were higher,the difference was statistically significant(t=83.999, 75.857, 49.051, 50.809, 45.185, 95.472, P<0.05);as for the comparison between the two groups, study group prealbumin(PA) was lower,the difference was statistically significant(t=890.688, P<0.05);serum adenosine deaminase(ADA), total bile acid(TBA), hyaluronic acid(HA), laminar adhesion Protein(LN) and type Ⅲ procollagen(PC-Ⅲ) were higher,the difference was statistically significant(t=179.919, 329.609, 285.069, 18.122, 54.908, P<0.05). Conclusion Because patients with liver cirrhosis are accompanied by a variety of abnormal biochemical indicators,the use of biochemical test items in the diagnosis of liver cirrhosis can not only provide data support for the early diagnosis of liver cirrhosis, but also can effectively assess the patient’s disease and prognosis.