克拉霉素联合替硝唑治疗小儿胃炎的价值研究

Study on the Value of Clarithromycin Combined with Tinidazole in the Treatment of Gastritis in Children

目的对小儿胃炎患者采用克拉霉素联合替硝唑治疗的效果进行探究。方法选择该院收治的小儿胃炎患儿126例作为该次纳入的对象,选取时间段为2018年8月—2020年5月。通过随机盲选的方式对两组予以分组处理,其中甲组有63例,乙组有63例。通过常规治疗对甲组予以治疗,通过克拉霉素联合替硝唑对乙组予以治疗。比较两组的疗效。结果较之于甲组的总有效率80.9%,乙组的总有效率为96.8%,明显更高,差异有统计学意义(χ^(2)=8.036,P<0.05);乙组的早饱症状评分(1.4±0.4)分、嗳气症状评分(0.5±0.2)分、腹痛评分(1.7±0.4)分、腹胀评分(1.1±0.6)分明显低于甲组(2.9±0.7)分、(1.3±0.5)分、(3.0±0.6)分、(2.5±0.9)分,差异有统计学意义(t=14.767、11.791、14.309、10.273,P<0.05);较之于甲组的不良反应发生率15.9%,乙组的不良反应率为3.2%,明显更低,差异有统计学意义(χ^(2)=5.895,P<0.05)。结论在小儿胃炎的临床治疗中,应用克拉霉素联合替硝唑进行治疗可以达到很好的效果,而且还可以改善其临床症状,不良反应少,具有较好的安全性。

Objective To explore the effect of clarithromycin combined with tinidazole in the treatment of children with gastritis.Methods 126 children with pediatric gastritis admitted to the hospital were selected as the subjects of this inclusion,and the selected time period was from August 2018 to May 2020.The two groups were divided into groups by random blind selection,including 63 cases in group A and 63 cases in group B.Group A was treated with conventional treatment,and group B was treated with clarithromycin combined with tinidazole.Compared the efficacy of the two groups.Results Compared with the total effective rate of 80.9%in group A,the total effective rate in group B was 96.8%,which was significantly higher.The difference was statistically significant(χ^(2)=8.036,P<0.05);compared with the early satiety symptom score of group B(1.4±0.4)points,belching symptom score(0.5±0.2)points,abdominal pain score(1.7±0.4)points,abdominal distension score(1.1±0.6)points,significantly lower than group A(2.9±0.7)points,(1.3±0.5)points,(3.0±0.6)points,(2.5±0.9)points,the difference was statistically significant(t=14.767,11.791,14.309,10.273,P<0.05);compared with the adverse reaction rate of 15.9%in the group A,the adverse reaction rate of 3.2%in the group B was significantly lower,the difference was statistically significant(χ^(2)=5.895,P<0.05).Conclusion In the clinical treatment of pediatric gastritis,clarithromycin combined with tinidazole can achieve good results,and it can also improve the clinical symptoms,with fewer adverse reactions and good safety.