加巴喷丁联合复方倍他米松治疗带状疱疹后遗神经痛的疗效研究

Efficacy of Gabapentin Combined with Compound Betamethasone in the Treatment of Postherpetic Neuralgia

目的探讨对带状疱疹后遗神经痛患者采用加巴喷丁+复方倍他米松药物进行治疗后获得临床效果。方法将该院2016年9月—2020年7月收治的54例带状疱疹后遗神经痛患者按数字奇偶法分组,联合组(27例):采用加巴喷丁+复方倍他米松药物完成后遗神经痛治疗;单一组(27例):采用复方倍他米松药物完成后遗神经痛治疗;就组间总后遗神经痛疗效数据、睡眠质量评分量表(QS)评分、疼痛视觉模拟评分法(VAS)评分、P物质(SP)、β-内咖肽(β-EP)展开对比。结果联合组带状疱疹后遗神经痛患者总疗效数据(96.30%)高于单一组(70.37%),差异有统计学意义(χ^(2)=4.800,P<0.05);治疗前,联合组带状疱疹后遗神经痛患者QS评分(2.85±0.52)分、VAS评分(8.49±1.69)分、SP(103.49±24.13)ng/L以及β-EP(32.25±9.59)ng/L,单一组QS评分(2.87±0.49)分、VAS评分(8.59±1.49)分、SP(102.39±26.25)ng/L、β-EP(31.19±10.36)ng/L,差异无统计学意义(t=0.145、0.230、0.160、0.390,P>0.05);治疗后,联合组QS评分(0.49±0.22)分、VAS评分(2.02±0.25)分、SP(56.69±14.69)ng/L、β-EP(48.59±3.13)ng/L分,单一组QS评分(1.39±0.39)分、VAS评分(3.85±0.55)分、SP(81.39±16.25)ng/L、β-EP(42.49±2.52)ng/L,差异有统计学意义(t=10.444、15.739、5.858、7.887,P<0.05)。结论加巴喷丁+复方倍他米松药物联合应用,可使带状疱疹后遗神经痛患者疼痛程度获得显著缓解,将其睡眠质量进行有效改善,使得临床疗效获得明显增强,对于SP产生进行显著抑制,对于β-EP释放加以有效促进,最终实现带状疱疹后遗神经痛患者有效预后。

Objective To explore the clinical effects of gabapentin+compound betamethasone in patients with postherpetic neuralgia.Methods 54 patients with herpes zoster post-neuralgia who were admitted to the hospital from September 2016 to July 2020 were divided into groups by the digital parity method,the combined group(27 cases):gabapentin+compound betamethasone was used to complete the sequelae pain treatment;single group(27 cases):the use of compound betamethasone drugs to complete the treatment of sequelae neuralgia;the efficacy data of the total sequelae neuralgia between the groups,sleep quality scale(QS)score,visual analogue pain score(VAS),Substance(SP),β-endogypeptide(β-EP)to expand the comparison.Results The total efficacy data of patients with postherpetic neuralgia in the combined group(96.30%)was significantly higher than that of the single group(70.37%),the difference was statistically significant(χ^(2)=4.800,P<0.05);before treatment,the combined group had postherpetic neuralgia patients’QS score(2.85±0.52)points,VAS score(8.49±1.69)points,SP(103.49±24.13)ng/L andβ-EP(32.25±9.59)ng/L,the single group had QS score(2.87±0.49)points,VAS score(8.59±1.49)points,SP(102.39±26.25)ng/L andβ-EP(31.19±10.36)ng/L;there was no statistiaclly significant difference(t=0.145,0.230,0.160,0.390,P>0.05).After treatment,the combined group had QS score(0.49±0.22)points,VAS score(2.02±0.25)points,SP(56.69±14.69)ng/L andβ-EP(48.59±3.13)ng/L,the single group had the QS score(1.39±0.39)points,VAS score(3.85±0.55)points,SP(81.39±16.25)ng/L andβ-EP(42.49±2.52)ng/L,the difference was statistically significant(t=10.444,15.739,5.858,7.887,P<0.05).Conclusion The combined application of gabapentin and compound betamethasone can significantly relieve the pain of patients with postherpetic neuralgia and effectively improve their sleep quality,which significantly enhances the clinical efficacy and significantly inhibits the production of SP.Effectively promote the release ofβ-EP,and finally achieve an effective prognosis for patients with postherpetic neuralgia.