醒脑静联合依达拉奉治疗重症脑出血的疗效探讨

Study on the Effect of Xingnaojing Combined with Edaravone in the Treatment of Severe Cerebral Hemorrhage

目的探讨醒脑静联合依达拉奉治疗重症脑出血的疗效。方法重症脑出血患者均在2018年1月—2019年12月期间进入该院接受治疗,自其中随机抽取60例并以盲选法将患者分为常规组、观察组,每组30例,常规组给予依达拉奉治疗,观察组给予醒脑静联合依达拉奉治疗,对比两组治疗效果、脑血肿情况以及预后效果。结果观察组治疗总有效率为93.33%显著高于常规组73.33%,差异有统计学意义(χ^(2)=4.320,P<0.05)。两组在治疗之前脑血肿体积、脑水肿体积对比,差异无统计学意义(t=0.045、0.132,P>0.05);两组在治疗后血肿体积、脑水肿体积对比,观察组显著低于常规组,差异有统计学意义(t=2.036、2.433,P<0.05)。两组在治疗之前神经功能缺损(NIHSS)评分、格拉斯哥昏迷指数(GCS)评分对比,差异无统计学意义(t=1.630、0.337,P>0.05);两组在治疗后NIHSS评分、GCS评分对比,观察组显著优于对照组,差异有统计学意义(t=8.434、4.381,P<0.05)。结论重症脑出血使用醒脑静联合依达拉奉治疗可以有效提升治疗有效率,对于脑血肿和脑水肿的清除效果更好,同时可以对神经功能进行保护,对预后具有改善效果。

Objective To explore the effect of Xingnaojing combined with edaravone in the treatment of severe cerebral hemorrhage.Methods Patients with severe intracerebral hemorrhage were admitted to the hospital for treatment from January 2018 to December 2019.Among them,60 cases were randomly selected and the patients were divided into routine group and observation group by blind selection,with 30 cases in each group.The routine group was treated with edaravone,and the observation group was treated with Xingnaojing combined with edaravone.The treatment effect,cerebral hematoma situation and prognostic effect of the two groups were compared.Results The total effective rate of treatment in the observation group was 93.33%significantly higher than that in the routine group 73.33%,the difference was statistically significant(χ^(2)=4.320,P<0.05).There was no significant difference in the volume of cerebral hematoma and cerebral edema between the two groups before treatment,the difference was not statistically significant(t=0.045,0.132,P>0.05);the volume of hematoma and cerebral edema of the two groups after treatment was significantly lower than that of the routine group,the difference was statistically significant(t=2.036,2.433,P<0.05).The comparison of NIHSS score and GCS score between the two groups before treatment had no significant difference,the difference was not statistically significant(t=1.630,0.337,P>0.05);the comparison of NIHSS score and GCS score between the two groups after treatment was significantly better than the routine group,the difference was statistically significant(t=8.434,4.381,P<0.05).Conclusion The treatment of severe cerebral hemorrhage with Xingnaojing combined with edaravone can effectively improve the treatment efficiency,and has a better effect on clearing cerebral hematoma and cerebral edema.At the same time,it can protect the nerve function and improve the prognosis.