摘要
Using bioinformatics methods,79 functional SNPs of 44 finger bone development genes potentially related to the formation of digit ratio were selected.In our study,the relationship between 2D:4D and the above SNPs genotyped by using multiple PCR method was evaluated in a Ningxia population(400 men and 408 women).L2D:4D was statistically different among different genotypes of rs3809346(COL4A2)in whole population and female;R2D:4D was different among genotypes in the female and the genotype carrying minor allele A had increased R2D:4D in the additive genetic model.L2D:4D was statistically different among rs3825490(COL4A2)in the whole population and male,and L2D:4D of T/T genotype under recessive model was higher than the C/C-T/C genotype.A statistical difference was found in different genotypes of rs7984100(COL4A2)in the whole population.L2D:4D differed among different genotypes for rs1042917(COL6A2).L2D:4D in women was significantly different among rs2839110(COL6A2).L2D:4D in females was different between genotypes of rs755793(FGFR2)gene.R2D:4D was statistically different in genotypes of rs17576(MMP9).
出处
《解剖学杂志》
CAS
2021年第S01期14-14,共1页
Chinese Journal of Anatomy