SorCS2 neurofibrillary tangles-like lesions in AD human cerebrum

Recent findings have indicated that SorCS2,a member of the vacuolar protein sorting 10 protein(VPS10P)family,has relevance to bipolar disorder,schizophrenia,and Alzheimer's disease(AD).We observed SorCS2 can accumulate as neurofibrillary tangles(NFTs)-like lesions in AD human brain cerebrum.Then we set to explore NFTs-like lesions from SorCS2 in aged and AD human cerebrum,and whether this pathological hallmark is unique to AD human brains.We characterized SorCS2 changes in postmortem human brains(n=10)from aged and AD subjects.