Protective effect of testosterone on endogenous apoptosis induced by Aβ42 in HT22 cells

Aβhas attracted a great deal of interest in the field of Alzheimer'diseases(AD)research,and its influence on the cells and the neuronal system,has been a pressing issue to clarify with a goal of diagnostic and therapeutic development.In our study,we determine whether mitochondrial impairment by Aβis fatal enough to cause neuronal death in AD conditions.Using Western blot to detect the expression of Bax and Bel-2,we verified incubatina HT22cells with 10 nmol/L Aβfor 24 h had the significant effect on cell apoptosis.