A systematic analysis of key genes and signaling pathways identifies a signature for neuropathic pain after spinal cord injury

Spinal cord injury(SCI) damages sensory systems,producing chronice neuropathic pain that is refractory to medical treatment.The specific mechanisms that underlie SCI-induced neuropathic pain(SCI-NP)remain unclear,and protein biomarkers have not yet been integrated into diagnostic screening.To better understand the host molecular pathways involved in SCI-NP,we used a bioinformatic approach to identify target genes and their associated functions,pathways and networks.