A TET1-miR-30b-Nav1.6 pathway indorsal root ganglia participates in oxaliplatin-induced neuropathic pain

Anti-cancer chemotherapy is.usually associated withperipheral neurotoxicity,which may result in severe pain hypersensitivity.Our previous study verified that miR-30b mediated the up-regulation of voltage gated sodium channel 1.6(Nav1.6)in the dorsal root ganglia(DRG)of rats with oxaliplatin(OXA)-induced neuropathic pain(OIPN).However,the mechanism of how miR-30b is changed remains elusive.In the current study,we found that the level of TET1 as well as the hydroxymethylation level in miR-30b promotor were significantly decreased in the L3-L5 DRG of OIPN mice.