Differential expression of related molecules after acute injury of rabbits'anterior cruciate ligament and medial collateral ligament

The drastic difference in healing capacity between the anterior cruciate ligament and medial collateral ligament injuries is still largely unexplained.So,studying the molecular expression after anterior cruciate ligament and medial collateral ligament injury could be a new direction to explain such differences.In this study,eighteen male 3-month-old New Zealand white rabbits were randomly divided into six groups by injury modeling to study the molecular expression after anterior cruciate ligament and medial collateral ligament injury.The expression of molecular genes and proteins was examined using reverse transcriptase chain reaction and Western blotting.Marked differences were found in the postinjury changes in gene levels and proteins in the anterior cruciate ligament compared to the medial collateral ligament.The results show that there were drastic differences in angiogenesis,collagen and matrix metalloproteinases after anterior cruciate ligament and medial collateral ligament injury.It can be found that the repair ability of the anterior cruciate ligament and medial collateral ligament after injury may be related to the differences in molecular expression.