Immunocontraceptive effects of ACRBP epitope-based vaccines in mice

Acrosin binding protein(ACRBP)is restrictedly expressed in sperm acrosomes and involved in many important reproductive processes.Here we investigated the immunocontraceptive effects of ACR BP peptide-based vaccines.B-cell epitope vaccines of mouse ACRBP were predicted by bioinformatics and prepared by vector coupling and adjuvant combination.Subsequently,female mice were actively immunized with the epitope vaccines subcutaneously,and the titers and specificity of anti-ACRBP antibodies were detected.Then the efficancy,safety and reversibility of epitope vaccines for contraception were evaluated in vivo and in vitro.