Characterization of serum estradiol level and tissue estrogen receptor immunostaining with clinical response reproductive factor changes in Chinese female patients with esophageal squamous cell carcinoma

The prognostic value of estrogen and/or ER on female pa tients with esophageal squamous cell carcinoma(ESCC)is rarely reported.Current study was undertaken to elucidate the associations of serum estradiol level,tissue estrogen receptor alpha(ERa)and estrogen receptor beta(ERβ)expression with clinical response and reproductive factor changes in 387 female ESCC patients.A genome-wide association study on 3921 ESCC patients using 40 SNPs(P≤1×10^(-7))demonstrated that rsl SNP with AA,GG or GA genotype was significantly difference(X^(2)=12.258,8.399,6.671;P=0.002,0.015,0.036)on overall survival.