非甾体类抗炎药在奶牛产后疾病中的应用

Application of non-steroidal anti-inflammatory drugs in postpartum diseases of dairy cows

非甾体类抗炎药(non-steroidal anti-inflammatory drugs,NSAID)是治疗炎性疾病的常用药物,对奶牛分娩痛、产后子宫炎和子宫内膜炎以及乳腺炎等多种疾病具有显著作用。在奶牛,NSAID通过调控NF-κB、MAPK和WNT/β-catenin等多条通路抑制环氧化酶的活性继而发挥抗炎作用。治疗奶牛疾病的常见NSAID包括氟尼新葡甲胺、美洛昔康和酮洛芬等。大量研究表明,不同NSAID治疗奶牛产后疾病的效果也不同。由于NSAID存在明显的不良反应和在我国奶牛疾病中的普遍应用,其对奶牛产后机能恢复的影响未引起重视。为指导奶牛临床科学合理用药和促进奶牛产后机能恢复,本文对此类药物在奶牛产后子宫感染和乳腺炎的治疗方面做一综述。

Non-steroidal anti-inflammatory drugs(NSAID)are commonly used in the treatment of inflammatory diseases in dairy cows and showed therapeutic effects on many disease processes such as pain in delivery,postpartum metritis,endometritis and mastitis.In dairy cows,NSAID inhibits the activity of cyclooxygenase and plays an anti-inflammatory role by regulating the NF-κB,MAPK and Wnt/β-catenin pathways.The common NSAIDs for the treatment of cow diseases include flunixin meglumine,meloxicam and ketoprofen.A large number of reports showed that different NSAIDs have different effects on postpartum diseases of dairy cows.As NSAID has obvious adverse reactions and has been widely used in dairy cows in China,its effect on postpartum functional recovery of dairy cows has not received sufficient attention.In order to guide the clinical rational use of the drugs and to promote the recovery of postpartum function in dairy cows,this paper reviews the applications of NSAIDs against the postpartum uterine infections and mastitis in dairy cows.