骨髓脂肪细胞与白血病发生的相关性研究进展

Advances on the Correlation between Bone Marrow Adipocytes and Leukemia Development

骨髓脂肪组织是一种存在于成人外周骨和远端骨内的脂肪组织。既往研究对骨髓脂肪组织功能的认识尚不明确,认为脂肪组织以空间占据为主,是骨髓造血功能减退的表现。近年来,随着研究的不断深入,有较多的研究认为脂肪细胞具有内分泌器官的功能,能作为骨髓微环境的成分影响多种疾病的转归。研究发现,在多种不同类型的白血病(包括急性髓系白血病、急性淋系白血病、慢性白血病等)中均存在着骨髓脂肪细胞代谢的异常,这种异常对疾病的发生发展及预后起一定作用。更好地系统了解血液病中骨髓脂肪细胞的功能,调控脂肪细胞与白血病细胞间的交互作用,并调节骨髓脂肪细胞的代谢过程,对今后白血病的治疗可能会具有重要意义。

BMAT (bone marrow adipose tissue) is a kind of adipose tissue that exists in the peripheral and distal bones of adults.The function of MAT was not fully clarified based on previous studies,most of which believed that it only played a role as spatial occupation,and showed as hypohematopoiesis.With the developing knowledge of bone marrow microenvironment,more and more studies found that adipocyte worked as endocrine organs and was related to the outcome of many diseases.Based on the current studies,abnormal metabolism of bone marrow adipocytes has been found in many types of leukemia (acute myeloid leukemia,acute lyphoctic leukemia,as well as chronic leukemia),which was believed to contribute to its development,and have a significance on its prognosis.Better understanding the role of BMAT in hematologic disease,trying to figure out the interaction between bone marrow adipocytes and leukemic cells,and work on regulating the metabolism of BMAT may be of great significance in leukemia management in the near future.