TMEM16A在上皮细胞中的表达和调控

Expression and Regulation of TMEM16A in Epithelial Cells

TMEM16A(tranmenbrane protein 16A)作为一种已知的钙激活氯离子通道(calcium-activated chloride channel,CaCC)在机体中广泛表达,并介导多种重要的生理功能。在上皮细胞中,TMEM16A可以通过多级反应介导细胞的膜电位变化和液体分泌。此外,在多种炎症相关的上皮组织疾病如囊性纤维化、哮喘和急性胰腺炎中均发现TMEM16A表达上调的现象,调节TMEM16A的表达和通道活性可能是炎症治疗的一种潜在策略。研究TMEM16A在上皮细胞中的表达和调控机制,对阐明TMEM16A的生理病理功能具有重要意义。该文就上皮细胞中TMEM16A的研究进展进行综述。

TMEM16A (tranmenbrane protein 16A) is widely expressed in the body as a known CACC (calcium-activated chloride channel),which mediates many important physiological functions.In epithelial cells,TMEM16A can mediate membrane potential changes and fluid secretion through multiple reactions.In addition,TMEM16A expression is up-regulated in a variety of inflammation-related epithelial diseases,such as cystic fibrosis,asthma and acute pancreatitis;regulating TMEM16A expression and channel activity may be a potential strategy for the treatment of inflammation.Studying the expression and regulation mechanism of TMEM16A in epithelial cells is of great significance for elucidating the physiological and pathological functions of TMEM16A.Here,this artical reviewed the latest research progress of TMEM16A in epithelial cells.