局部进展期直肠癌新辅助化疗的研究进展

Research progress in neoadjuvant chemotherapy for locally advanced rectal cancer

直肠癌发病率和死亡率在我国居高不下,术前新辅助同步放化疗和全直肠系膜切除术的标准化治疗方案已大大降低了直肠癌局部复发的风险,但未能提高总生存率(OS)。目前已有研究表明放射治疗对肛门功能、排尿功能和性功能产生影响,为尽量减少与治疗有关的毒性并改善OS,摒弃放疗的单纯新辅助化疗再手术可能是另一种更佳的选择。本文旨在阐明新辅助化疗在局部进展期直肠癌的研究现状和可行性分析。

The incidence and mortality of rectal cancer remain high in China.Standardized preoperative regimen of neoadjuvant chemoradiotherapy and total mesorectal excision has significantly reduced the risk of local recurrence of rectal cancer,but has not improved overall survival(OS).At present,radiotherapy has been shown to affect anal function,urination function,and sexual function.To minimize treatment-related toxicity and improve OS,reoperation with neoadjuvant chemotherapy without radiotherapy may be a better option.This review aimed to clarify the research status and feasibility of neoadjuvant chemotherapy in locally advanced rectal cancer.