蛋白酪氨酸磷酸酶受体J在乳腺癌组织中的表达及其与临床预后的相关性

Expression of protein tyrosine phosphatase receptor J in breast cancer tissues and its relationship with clinical prognosis

目的:探讨蛋白酪氨酸磷酸酶受体J(PTPRJ)在乳腺癌中的表达,并分析其与临床病理指标和预后的关系。方法:应用免疫组化SP法检测198例乳腺癌组织及其配对癌旁正常组织中PTPRJ的表达情况,并分析PTPRJ表达与乳腺癌临床病理指标及预后的关系。结果:免疫组化染色结果显示PTPRJ在癌旁正常组织中的表达显著高于乳腺癌组织(P=0.003),PTPRJ表达水平与淋巴结转移(P=0.014)、TNM分期(P=0.003),ER状态相关(P=0.048)。Kaplan-Meier生存分析显示PTPRJ低表达组患者的总生存率明显低于PTPRJ高表达组(P=0.002)。多因素COX比例风险模型分析显示TNM分期和PTPRJ表达是影响患者总生存的独立预后因素。结论:PTPRJ在乳腺癌中低表达,与肿瘤进展密切相关,可作为评价乳腺癌患者预后的有效指标之一。

OBJECTIVE:To evaluate expressions of protein tyrosine phosphatase receptor J(PTPRJ)in breast cancer tissues and their roles in clinical process.METHODS:The immunohistochemical SP method was used to detect expressions of PTPRJ in normal breast and breast cancer tissues.Then,relationships between PTPRJ expressions,and clinicopathological parameters and survival prognosis of breast cancer patients were analyzed.RESULTS:Results from immunohistochemical staining show that expressions of PTPRJ in normal breast tissues were significantly higher than that in breast cancer tissues(P=0.003).PTPRJ expressions were significantly correlated with lymph node metastasis(P=0.014),TNM stages(P=0.003)and ER status(P=0.048).Kaplan-Meier analyses reveal that breast cancer patients with low PTPRJ expressions in tumors had significantly worse overall survival rates than those with higher PTPRJ expressions(P=0.002).Multivariate analyses show that TNM stages and PTPRJ expressions were independent survival predictors.CONCLUSION:Our data indicates that expressions of PTPRJ were reduced in breast cancer tissues and were closely related to tumor progression.Therefore,PTPRJ expression can possibly be used as a valuable marker for prognosis in patients with breast cancers.