以超高分子材料为载体研发新型固体缓释抑菌剂

Research and Development of New Type of Solid Sustained-Release Bacteriostatic Agent With Ultra-High Molecular Material as Carrier

利用超高分子材料载体制备一种固体缓释抑菌剂,对其进行表征,检验其缓释及抑菌效果.将挥发性中西药复配抑菌液吸附于特定的超高分子材料载体,对超高分子材料的力学性能进行考察,观察其微观结构,并对固体缓释抑菌剂的缓释效果和抑菌效果进行评价.结果表明:超高分子材料的拉伸断裂应力为28.79 MPa,抗冲击强度为78.85 kJ·m^(-2),超高分子材料的孔隙率为69.17%,抑菌液吸附量为0.58 g·cm^(-3),抑菌液吸附率为141.38%;固体缓释抑菌剂的有效释放时长为10 d,对多种致病菌的平均杀灭率均高于99%;超高分子材料具有高强度的力学性能和较高的抑菌液吸附率;固体缓释抑菌剂释放速率稳定,在空气中分布均匀,缓释效果和抑菌效果良好.

A kind of solid sustained-release bacteriostatic agent was prepared by using ultra-high molecular material,and characterized to test its sustained-release and antibacterial effect.The volatile Chinese and Western medicine compound bacteriostatic solution was adsorbed on the specific ultra-high molecular materials carrier,the mechanical properties of the ultra-high molecular materials were investigated,their microstructure was observed,and the sustained-release effect and antibacterial effect of the solid sustained-release bacteriostatic agent were evaluated.The results showed that the tensile fracture stress of the ultra-high molecular materials was 28.79 MPa,the impact strength was 78.85 kJ·m^(-2),the porosity was 69.17%,and the adsorption capacity and adsorption rate of the bacteriostatic solution were 0.58 g·cm^(-3)and 141.38%respectively.The effective release time of the solid sustained-release bacteriostatic agent was 10 d,and the average killing rate of various pathogenic bacteria exceeded 99%.It indicates that the ultra-high molecular materials have high strength mechanical properties and high bacteriostatic solution adsorption rate.In addition,the release rate of solid sustained-release bacteriostatic agent is stable,the distribution in the air is uniform,and the sustained-release effect and and antibacterial effect are both good.