摘要
以2-甲基烟腈为原料,NBS为溴代试剂,BPO为引发剂,在四氯化碳溶液中发生自由基溴代反应得到2-(溴甲基)烟腈,产物结构通过1H NMR和ESI-MS表征。并考察确定了该溴代反应的适宜条件为:NBS用量为nNBS∶n2-甲基烟腈=1.2∶1,反应溶剂为四氯化碳,反应温度60℃,反应时间7h,在该条件下,产物收率达到61.4%。
Using 2-methylnicotinonitrile as raw material,NBS as bromination reagent and BPO as initiator,2-(bromomethyl)nicotinonitrile was obtained by free radical bromination in tetrachloromethane solution,and its structure was characterized by ^(1)H NMR and ESI-MS.The optimum conditions of the bromination reaction were as follows:the dosage of NBS is:n_(NBS)∶n2_(-methylnicotinonitrile)=1.2∶1,the reaction solvent was tetrachloromethane,the reaction temperature was 60℃,the reaction time was 7h,the yield of the product was up to 61.4%by this reaction conditions.
作者
仝红娟
赵梅梅
杜漠
刘斌
问娟娟
TONG Hong-juan;ZHAO Mei-mei;DU Mo;LIU Bin;WEN Juan-juan(School of Pharmacy,Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China)
出处
《化学工程师》
CAS
2021年第7期7-8,57,共3页
Chemical Engineer
基金
陕西省自然科学基础研究计划(2019JQ-924)
陕西省中药绿色制造技术协同创新中心重点培育项目(2019XT-1-03)
陕西省教育厅2020年度专项科学研究计划(20JK0510)。
关键词
芳香腈化合物
苄溴
溴代反应
合成
aromatic nitrile compounds
benzyl bromide
bromination reaction
synthesis
